强骨饮治疗原发工型骨质疏松性髋部骨折的临床研究

目的：观察自拟中药强骨饮对原发I型骨质疏松性髋部骨折患者骨矿密度、骨折愈合、骨转换生化指标等方面的影响。方法：对65例原发I型骨质疏松性髋部骨折患者行手术治疗后，采用双能X线骨密度测量仪（法国Midlink公司生产），分别测腰椎正位（L1-4）和健侧股骨颈（Neck），Wards三角及大转子（Torch）（单位为g／cm。），并测定骨转换生化标志物：骨特异性碱性磷酸酶（BALP）、血清抗酒石酸酸性磷酸酶5b（sTRACP5b）。随后随机将患者分为治疗组（33例）及对照组（32例）。治疗组服用自拟中药强骨饮，日1剂，早晚温服；对照组则服用仙灵骨葆胶囊，每次3粒，每日2次，两组共服用药物6个月。患者于治疗后每月行x线拍片检查，观察骨折断端生长情况；治疗6个月后再次测定腰椎正位（L1-4）和健侧股骨颈（Neck），Wards三角及大转子四个部位骨密度值及BAI。P、sTRACP5b，并进行比较。结果：治疗6个月后，中药强骨饮组4个部位的BMD较治疗前均有好转（P〈0．05）；治疗后组间比较，治疗组Wards三角骨密度改善优于对照组（P〈O．05），治疗组骨折愈合时间较对照组明显缩短，两组比较差异有统计学意义（P〈0．05）；治疗组治疗后骨转换生化标志物与对照组比较差异有统计学意义（P〈0．05）。结论：自拟q-药强骨饮治疗原发I型骨质疏松性髋部骨折，能有效提高骨密度，改善骨代谢，并促进了骨折的愈合。

Clinical Research of Type I Primary Osteoporotic Hip Fractures Treated by Qiangguyin

Objective：To observe the effects of Qiangguyin（GGY） on the bone mineral density （BMD）, the fracture healing and biochemical indicators of bone metabolism in type I primary osteoporotic hip fracture patients. Methods：The bone alka- line phosphates （BALP） and serum tartrate--resistant acid phosphates 5b （sTRACP5b）, BMD of femoral neck, great tro- chanter, lumber 1～4 and Ward region were detected in 65 patients with hip osteoporosis fracture after surgery. They were randomly divided into two groups. Thirty-three patients in the treated group took GGY, twice a day, while 32 patients in the control group took Xianlinggubao capsules 150mg each time, twice a day. The therapeutic course for both groups was three months. X-ray examination was taken every month to observe the bony curative effect, and BALP, sTRACP5b, and BMD were detected again after patients were treated for 6 months. Results： After 6 months treatment, the BMD of the four parts in the treatment group increased significantly （P〈0.05）. There was significant difference in the BMD of the Ward region between the treatment group and the control group （P〈0.05）. The fracture healing time in the treated group was shorter than that in the control group （P〈0.05）. Significant difference was found in the two biochemical indicators of bone metabolism between the two groups after treatment （P〈0.05）. Conclusion： GGY can increase BMD effectively, improve the bone metabolism and promote bony union.