川芎嗪对大鼠脊髓损伤段电解质、水含量改变的保护作用

目的:了解川芎嗪对损伤的脊髓组织的保护作用.方法:采用改良Allen氏WD装置以50 g·cm(10 g×5 cm)冲击棒打击致伤大鼠T8脊髓节段.术后实验组用川芎嗪注射液静脉注射,对照组等量生理盐水静脉注射.术后1 h、6 h、12 h及24 h取脊髓损伤段标本,分别采用干湿法、原子吸收光谱法测量脊髓损伤段电解质、水含量.结果:损伤脊髓后,伤区钙、钠离子升高、钾离子降低;水含量增高、应用川芎嗪后电解质紊乱情况和水肿得到改善.结论:川芎嗪对受伤脊髓段电解质、水含量改变有一定保护作用.

The Protecting Effect of Tetramethipyazine on the Change of Water and Electrolytc in the Injured Spined Cord Section in Rat

Objective:To study the effect of tetramethipyzine on protecting injured spinal cord.Methods:72 rates were divided randomly into three groups.The first group (A) included 8 rates was served as control.The second (B) and third group (C) had 32 rates in each.The injury at the level L8 spinal segment of the rates in group B and C were made by dropping a weight of 10 g from a high 5 cm after a total laminectomy from L8 segments.Rates in group C were given Tetramethipyazine while those in group B had the same volume of nomal saline.At 1,6,12,24 hours following surgery,8 rates in each group were sacrificed and the injured segments were resected for examination.The content of water and electrolyte was measured by dry-wet method and atomic absorption spectroscopy.Results:A significant water,Ca 2+ and Na+ content increase in B and C group were seen by companision with pre-injury,but K+ decrease,while in group C the value of water and Ca 2+ and Na+ were significantly lower than that of group B.Conclusions:Tetramethipyazine can refrain the abnomal change of water and electrolyte in the injured spinal cord section of rates and has some effects on spinal cord in rat.