三黄安消胶囊治疗2型糖尿病及改善胰岛素抵抗作用的临床研究

目的：观察三黄安消胶囊治疗2型糖尿病及改善胰岛素抵抗（IR）的作用。方法：将60例2型糖尿病IR患者随机分为2组各30例。2组基础治疗相同，治疗组加用三黄安消胶囊（由黄芩、黄连、人参等组成）治疗。8周为1疗程。主要观察治疗前后空腹血糖（FBG）及餐后2小时血糖（P2BG）、空腹血胰岛素（FINS）及餐后血胰岛素（PINS）、血压、血脂、体重等指标的变化，并计算胰岛素敏感性指数（IAI）和胰岛素抵抗指数（HOMA-IR）。结果：降血糖总有效率治疗组为83．3％，对照组为66．7％，2组比较，差异有显著性意义（P〈0．05）。治疗后治疗组FBG、P2BG、IAI、HOMA-IR均有明显改善，与治疗前比较，差异均有非常显著性意义（P〈0．01）；对照组仅P2BG有明显改善（P〈0．05）。治疗后治疗组与对照组FBG、HOMA-IR比较，差异均有非常显著性意义（P〈0．01）。结论：在基础治疗的同时加用三黄安消胶囊治疗2型糖尿病胰岛素抵抗患者，可显著改善胰岛素抵抗，并可调节血糖、血胰岛素、血压、血脂水平，对于肝肾功能无明显不良影响，临床使用具有较好的安全性。

A Clinical Study on Sanhuang Anxiao Capsule for Type Ⅱ Diabetes and Improvement of Insulin-Resistance

Objective: To observe the action of Sanhuang Anxiao Capsule (SAC) for type II diabetes and improvement of insulin-resistance (IR) .Methods: 60 cases of type II diabetes were allocated to 2 groups randomly (each group 30 cases) and were treated by basic treatment.The treatment group was added with SAC (composed of Radix Scutellariae,Rhizoma Coptidis, Radix Ginseng,etc.).8 weeks constituted a course of treatment. The fasting blood glycose (FBG),postprandial 2h blood glycose (P2BG),fasting blood insulin (FINS),postprandial blood insulin (PINS),blood pressure,blood - lipid,and body weight were observed and insulin sensitivity index (IAI) and insulin - resistance index (HOME-IR) were calculated.Results: In treatment group,the total hypoglycemic rate was 83.3% and 66.7% in treatment group and control group respectively (P<0.05) .After treatment,the P2BG,PINS and HOMA-IR were markedly improved in comparison with before treatment (P < 0.01).In control group,the FBG,P2BG,PINS and HOMA-IR were also markedly improved (P < 0.05) .After treatment,FBG and HOMA-IR of treatment group and control group showed very significant difference ( P < 0.01).Conclusion: The basic treatment with SAC simultaneously for type II diabetes with IR can markedly improve IR, regulate blood glycose,blood insulin,blood pressure and blood-lipid and exerts no adverse reaction on hepatic and renal function and is safe for clinical application.