银杏叶胶囊治疗脑卒中后轻度认知障碍临床研究

目的:观察银杏叶胶囊对脑卒中后轻度认知障碍患者认知功能及预后的影响。方法:选择100例脑卒中后轻度认知障碍患者,按随机数字表法分为观察组和对照组各50例。对照组给予西医对症治疗,观察组在对照组基础上给予银杏叶胶囊治疗。比较2组治疗前后蒙特利尔认知评估量表(MoCA)评分、脑部动脉血流速度、脑动脉硬化发生率、血管痉挛发生率以及血管狭窄发生率。结果:治疗前,2组MoCA评分比较,差异无统计学意义(P>0.05)。治疗后,2组MoCA评分均较治疗前升高(P<0.05),且观察组MoCA评分高于对照组(P<0.05)。治疗后,观察组大脑前动脉(ACA)、大脑中动脉(MCA)、大脑后动脉(PCA)、椎动脉(VA)、基底动脉(BA)的血流速度明显快于对照组(P<0.05)。治疗后,观察组脑动脉硬化发生率、血管痉挛发生率以及血管狭窄发生率均低于对照组(P<0.05)。结论:银杏叶胶囊可以改善脑卒中后轻度认知障碍患者的认知功能和脑部血流,降低血管狭窄发生率,临床疗效较好。

Clinical Study on Gingko Leaf Capsules for Mild Cognitive Impairment After Stroke

Objective:To observe the effect of gingko leaf capsules on cognitive function and prognosis in patients with mild cognitive impairment after stroke. Methods:A total of 100 cases of patients with mild cognitive impairment after stroke were divided into the observation group and the control group according to the random number table method,50 cases in each group. The control group was given symptomatic treatment of western medicine, and the observation group was additionally treated with gingko leaf capsules based on the treatment of the control group. Before and after treatment,the scores of Montreal Cognitive Assessment(MoCA),the blood flow velocity of cerebral arteries,and the incidences of cerebral arteriosclerosis,vasospasm and vascular stenosis in the two groups were compared. Results:Before treatment,there was no significant difference being found in the comparison of MoCA scores between the two groups(P>0.05). After treatment,the MoCA scores in the two groups were increased when compared with those before treatment(P<0.05),and the score in the observation group was higher than that in the control group(P<0.05). After treatment,the blood flow velocities of anterior cerebral artery(ACA), middle cerebral artery(MCA), posterior cerebral arteries(PCA), vertebral artery(VA) and basilar artery(BA) in the observation group were significantly faster than those in the control group(P<0.05). After treatment, the incidences of cerebral arteriosclerosis,vasospasm and vascular stenosis in the observation group were lower than those in the control group(P<0.05). Conclusion:Gingko leaf capsules can improve cognitive function and blood flow velocity in patients with mild cognitive impairment after stroke and reduce the incidence of vascular stenosis with good clinical effect.