尿毒清颗粒治疗慢性肾功能衰竭临床研究

目的:观察尿毒清颗粒治疗慢性肾功能衰竭(CRF)的临床疗效及其对钙磷代谢、结缔组织生长因子(CTGF)的影响。方法:选取120例CRF患者,按随机数字表法分为对照组和观察组各60例。对照组采用常规治疗,包括控制饮食、纠正酸碱、水电解质平衡;观察组在对照组的基础上加用尿毒清颗粒治疗。2组均连续治疗2个月,观察比较2组肾功能肌酐(SCr)、血尿素氮(BUN)]、血磷(P3-)、血钙(Ca2+)、甲状旁腺激素(PTH)、CTGF指标水平变化,并评定2组临床疗效及不良反应情况。结果:观察组总有效率为80.00%,对照组为61.67%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组SCr、BUN水平均较治疗前降低(P<0.05),且观察组SCr、BUN水平均低于对照组(P<0.05)。治疗后,2组PTH、CTGF、P3-水平较治疗前降低(P<0.05),Ca2+水平较治疗前升高(P<0.05);观察组PTH、P3-、CTGF水平均低于对照组(P<0.05),Ca2+水平高于对照组(P<0.05)。观察组不良反应发生率为3.33%,对照组为16.67%,2组比较,差异有统计学意义(P<0.05)。结论:尿毒清颗粒治疗CRF临床疗效显著,可有效调节钙磷代谢、CTGF平衡,改善肾功能,且安全性较高。

Clinical Study on Niaoduqing Granules for Chronic Renal Failure

Objective:To observe the clinical effect of Niaoduqing granules on chronic renal failure(CRF)and its effect on calcium and phosphorus metabolism and connective tissue growth factors(CTGF).Methods:A total of 120 patients with CRF were selected and divided into the control group and the observation group according to the random number table method,60 cases in each group.The control group received routine treatment,including diet control,acid-base balance correction,water and electrolyte balance;the observation group was additionally treated with Niaoduqing granules based on the treatment of the control group.The changes of kidney function indicators such as serum creatinine(SCr),blood urea nitrogen(BUN),blood phosphorus(P3-),blood calcium(Ca2+),parathyroid hormone(PTH)and CTGF in the two groups were observed and compared after two months of treatment,and the clinical effect and adverse reactions were evaluated.Results:The total effective rate was 80.00%in the observation group and 61.67%in the control group,the difference being significant(P<0.05).After treatment,the levels of SCr and BUN in the two groups were decreased when compared with those before treatment(P<0.05),and the above two levels in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of PTH,CTGF and P3-were decreased when compared with those before treatment(P<0.05),and the level of Ca2+was increased(P<0.05).The levels of PTH,CTGF and P3-in the observation group were lower than those in the control group(P<0.05),and the level of Ca2+was higher than that in the control group(P<0.05).The incidence of adverse reactions was 3.33%in the observation group and 16.67%in the control group,the difference being significant(P<0.05).Conclusion:Niaoduqing granules has a significant clinical effect on CRF,which can effectively regulate calcium and phosphorus metabolism,CTGF balance,improve kidney function,and is relatively safe.