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益气活血汤治疗早期糖尿病肾病40例疗效观察
引用本文:王秀芬,赵苍朵,张慧玲.益气活血汤治疗早期糖尿病肾病40例疗效观察[J].新中医,2006,38(4):46-47.
作者姓名:王秀芬  赵苍朵  张慧玲
作者单位:河北医科大学,第三医院,河北,石家庄,050051
摘    要:目的:观察益气活血汤治疗早期糖尿病肾病的临床疗效。方法:将60例患者随机分为2组。对照组20例给予一般饮食控制及降糖(糖适平、拜糖苹)治疗;治疗组40例在对照组治疗基础上加益气活血汤(处方:生黄芪、党参、翻白草、山莱萸、山药、生地黄、白术、当归、丹参、泽兰、桃仁、红花、大黄)治疗。观察治疗前后空腹血糖(FBG)、尿白蛋白排泄率(UAER)、组织型纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制物-1(PAI-1)的变化。结果:治疗组显效20例,有效14例,无效6例,总有效率为85%;对照组显效2例,有效5例,无效13例,总有效率为35%。2组总有效率比较,差异有非常显著性意义(P〈0.01)。治疗后治疗组UAER、PAI-1下降,t-PA上升,与对照组治疗后比较,差异有显著性或非常显著性意义(P〈0.05,P〈0.01)。结论:益气活血汤能治疗早期糖尿病肾病,机理可能与升高血t-PA,降低PAl-1,改善血液高凝状态有关。

关 键 词:糖尿病肾病  益气活血法  中药药理学
文章编号:0256-7415(2006)04-0046-02
收稿时间:2005-09-20
修稿时间:2005-09-20

Treatment of Early Stage of Diabetic Nephropathy by Yiqi Huoxue Tang: A Clinical Observation of 40 Cases
WANG Xiu-fen,ZHAO Cang-duo,ZHANG Hui-ling.Treatment of Early Stage of Diabetic Nephropathy by Yiqi Huoxue Tang: A Clinical Observation of 40 Cases[J].New Journal of Traditional Chinese Medicine,2006,38(4):46-47.
Authors:WANG Xiu-fen  ZHAO Cang-duo  ZHANG Hui-ling
Institution:The Third Hospital of Hebei University of Medical Sciences, Shijiazhuang 050051, China
Abstract:Objective: To observe the curative effect of Yiqi Huoxue Tang (YHT) for early stage of diabetic nephropathy (DN). Methods: 60 cases were allocated to 2 groups randomly. The control group (20 cases) was treated by general dietary control and hypoglycemic agents (glurenorum and acarbose), the treatment group (40 cases) based on the treatment of control group and added with YHT (composed of Radix Astragali, Radix Codonopsis, Herba Potentillae Discoloris, Fructus Corni, Rhizoma Dioscoreae, Radix Rehmanniae, Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Herba Lycopi, Semen Persicae, Flos Carthami and Radix et Rhizoma Rhei). The changes of fasting blood glucose, urinary albumin excretion rate (UAER), tissue plasminogen activator (TPA), plasminogen activator inhibitor - 1(PAI -1) were observed. Results: In treatment group, 20 cases were marked effective, 14 cases effective and 6 cases ineffective, the total effective rate was 85% , and 2, 5, 13 and 35% in control group respectively (P < 0.01). After treatment, the UAER and PAI -1 were decreased and TPA was in-creased in treatment group, the comparison with control group showed marked or very marked significant difference (P < 0. 05, P < 0. 01). Conclusion: The mechanism of YHT for early stage of DN may be related with the YHT can increase the blood TPA and lower PAI -1 and improve the hypercoagulability of blood.
Keywords:UAER  t-PA  PAI-1
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