益气通瘀汤联合西药治疗稳定型心绞痛临床研究

目的:观察益气通瘀汤联合西药治疗气虚血瘀型稳定型心绞痛的临床疗效。方法:选取120例确诊为气虚血瘀型稳定型心绞痛患者作为研究对象,随机分为治疗组和对照组,每组60例。对照组给予西医常规治疗,治疗组在对照组治疗的基础上联合益气通瘀汤治疗,对比2组患者治疗后的临床症状体征积分、心绞痛改善情况及血清内皮素-1(ET-1)、同型半胱氨酸(Hcy)、超敏C-反应蛋白(hs-CRP)水平及临床疗效。结果:治疗后,2组患者的临床症状体征积分、心绞痛发作次数及持续时间、ET-1、Hcy、hs-CRP水平均较治疗前明显下降,差异有统计学意义(P<0.05)。治疗后组间对比,治疗组临床症状体征积分、心绞痛发作次数及持续时间、ET-1、Hcy、hs-CRP水平均低于对照组,差异有统计学意义(P<0.05)。治疗组临床总有效率为91.7%,明显高于对照组的75.0%(P<0.05)。结论:益气通瘀汤联合西药治疗气虚血瘀型稳定型心绞痛临床疗效确切,较单用西药治疗能更好的改善患者的症状体征,降低患者血清ET-1、Hcy、hs-CRP水平,提高临床疗效,具有临床应用及研究价值。

Clinical Study on Yiqi Tongyu Tang Combined with Western Medicine for Stable Angina Pectoris

Objective:To observe the clinical effect of Yiqi Tongyu tang combined with western medicine for stable angina pectoris of qi deficiency and blood stasis type.Methods:A total of 120 cases of patients with stable angina pectoris of qi deficiency and blood stasis type were selected as the study subjects and randomly divided into the treatment group and the control group,60 cases in each group.The control group was given routine western medicine,and the treatment group was additionally treated with Yiqi Tongyu tang based on the treatment of the control group.After treatment,the scores of clinical symptoms and signs,the improvement of angina pectoris,the levels of endothelin-1(ET-1),homocysteine(Hcy)and highsensitivity C-reactive protein(hs-CRP)in serum and the clinical effect in the two groups were compared.Results:After treatment,the scores of clinical symptoms and signs,the frequency and duration of angina pectoris and the levels of ET-1,Hcy and hs-CRP in the two groups were significantly decreased when compared with those before treatment,the difference being significant(P<0.05);the above indexes in the treatment group were all lower than those in the control group,the difference being significant(P<0.05).The total clinical effective rate was 91.7%in the treatment group,significantly higher than that of 75.0%in the control group(P<0.05).Conclusion:The therapy of Yiqi Tongyu tang combined with western medicine has significant clinical effect in treating stable angina pectoris of qi deficiency and blood stasis type.Compared with that of simple western medicine,it can better improve symptoms,signs and clinical effect,and reduce the levels of ET-1,Hcy and hs-CRP in serum,which is worthy of clinical application and research.