易黄止带汤联合苦参凝胶治疗霉菌性阴道炎临床研究

目的:观察易黄止带汤联合苦参凝胶治疗霉菌性阴道炎(MV)的临床疗效。方法:选取MV患者120例,按随机数字表法分为对照组和观察组各60例。对照组给予酮康唑口服联合克霉唑栓治疗,观察组给予易黄止带汤口服及苦参凝胶阴道给药。比较2组治疗后临床症状消失时间、主要症状总积分、中医疗效、免疫球蛋白A(SIgA)、白细胞介素-2(IL-2)、IL-6、IL-8及降钙素原(PCT)表达情况。结果:观察组临床总有效率为90.00%,显著高于对照组77.70%(P<0.05)。观察组外阴瘙痒消失时间、白带恢复正常以及阴道黏膜充血消失时间均低于对照组(P<0.05)。治疗前,2组外阴瘙痒、尿急尿痛及白带量积分比较,差异无统计学意义(P>0.05)。治疗后,2组外阴瘙痒、尿急尿痛及白带量积分较治疗前降低(P<0.05),且观察组各症状积分均低于对照组(P<0.05)。治疗前,2组阴道分泌物中SIgA水平比较,差异无统计学意义(P>0.05)。治疗后,2组阴道分泌物中SIgA水平较治疗前升高,且观察组阴道分泌物中SIgA水平高于对照组(P<0.05)。治疗前,2组血清IL-2、IL-6、IL-8、PCT水平比较,差异无统计学意义(P>0.05)。治疗后,2组血清IL-2水平较治疗前升高,IL-6、IL-8、PCT水平较治疗前降低;且观察组血清IL-2水平高于对照组,IL-6、IL-8、PCT水平低于对照组;差异均有统计学意义(P<0.05)。结论:易黄止带汤联合苦参凝胶能缩短MV患者康复时间,提高免疫因子IL-2、SIgA表达,降低炎性反应,提高临床疗效,具有一定临床价值。

Clinical Study on Yihuang Zhidai Tang Combined with Kushen Gel for Mycotic Vaginitis

Objective:To observe the clinical effect of Yihuang Zhidai tang combined with Kushen gel for mycotic vaginitis(MV).Methods:A total of 120 cases of MV patients were divided into the control group and the observation group according to the random number table method,60 cases in each group.The control group was given oral administration of ketoconazole combined with clolrimazole suppositories,the observation group was treated with Yihuang Zhidai tang combined with Kushen gel based on the treatment of the control group.After treatment,the disappearance time of clinical symptoms,the total scores of the main symptoms,the curative effect of Chinese medicine and the expression of secretory immunoglobulin A(SIgA),interleukin-2(IL-2),interleukin-6(IL-6),interleukin-8(IL-8)and procalcitonin(PCT)in the two groups were compared.Results:The total clinical effective rate was 90.00%in the observation group,significantly higher than that of77.70%in the control group(P<0.05).The disappearance time of pruritus vulvae and congestion of vaginal mucosa and the recovery time of leukorrhea in the observation group were all shorter than those in the control group(P<0.05).Before treatment,compared the scores of pruritus vulvae,urgency of urination,urodynia and amount of leukorrhea in the two groups,there was no significance in the difference(P>0.05).After treatment,the scores of pruritus vulvae,urgency of urination,urodynia and amount of leukorrhea in the two groups were decreased when compared with those before treatment(P<0.05),and the above symptom scores in the observation group were all lower than those in the control group(P<0.05).Before treatment,compared the levels of SIgA in vaginal secretion in the two groups,there was no significance in the difference(P>0.05).After treatment,the levels of SIgA in vaginal secretion in the two groups were increased when compared with those before treatment,and the level in the observation group was higher than that in the control group(P<0.05).Before treatment,compared the levels of IL-2,IL-6,IL-8 and PCT in serum in the two groups,there was no significance in the difference(P>0.05).After treatment,the levels of IL-2 in serum in the two groups were increased when compared with those before treatment,and the levels of IL-6,IL-8 and PCT were decreased;the level of IL-2 in serum in the observation group was higher than that in the control group,and the levels of IL-6,IL-8 and PCT were lower;differences being significant(P<0.05).Conclusion:The therapy of Yihuang Zhidai tang combined with Kushen gel can shorten the rehabilitation time of MV patients,improve the expression of immune factors including IL-2 and SIgA,reduce inflammatory responses and enhance clinical effect,which has certain clinical value.