分泌性中耳炎患者血清中炎性介质ET-1微观辨证价值研究

目的：探讨分泌性中耳炎（SOM）患者血清内皮素-1（ET-1）含量与其辨证分型的关系，为其微观辨证提供临床实验依据。方法：收集SOM不同辨证分型患者风热型36例、湿热型38例、痰瘀型20例，正常组40例，采用ELISA法测定SOM各证型患者血清中炎性介质ET-1含量。结果：各证型血清ET-1含量比较，正常组显著低于风热型和湿热型（P〈0．01），但与痰瘀型无显著差异（P〉0．05）；风热型显著高于痰瘀型和正常组（P〈0.05，P〈0．01）；湿热型均显著高于风热型、痰瘀型和正常组（P〈0．05，P〈0．01，P〈0.01）；痰瘀型显著低于风热型（P〈0．01），但与正常组比较，差异无显著性意义（P〉0．05）。结论：各证型SOM患者血清中ET-1含量以湿热型最高，风热型次之，痰瘀型最低，3型之间差异显著，可以作为辨证分型的微观依据，提示血清中炎性介质ET-1对SOM患者微观辨证分型具有一定的参考价值。

Evaluation of Serum Inflammatory Mediator ET-1 in Microcosmic Syndrome Differen-tiation of Patients with Secretory Otitis Media

Objective:To investigate the relationship between TCM syndrome differentiation of secretory otitis media(SOM)and the serum level endothelin-1(ET-1)in SOM patients,so as to provide objective experimental basis for microcosmic syndrome differentiation.Methods:Ninety-four SOM patients which were differentiated as wind-heat type(n=36),damp-heat type(n=38),or phlegm and blood stasis type(n=20) were enrolled into the study.And 40 healthy volunteers were allocated to the normal group(n=40).Serum ET-1 content in ea...