虫草制剂治疗持续性不卧床腹膜透析患者34例临床观察

目的:观察人工虫草制剂对持续性不卧床腹膜透析(CAPD)患者临床症状、生化指标、免疫学指标和尿素清除指数(Kt/V)的干预治疗效果。方法:将67例慢性肾脏病5期进行CAPD治疗的患者随机分为2组,2组均接受CAPD治疗,在常规CAPD的基础上,治疗组加用人工虫草制剂口服,疗程6月。检测治疗前后血清总蛋白(TP)、白蛋白(Alb)、前白蛋白(PA)和血红蛋白(Hb)并同时检测血清IgA、IgG、IgM及Kt/V值,观察疗程中2组腹膜透析相关感染(腹膜炎和隧道出口处感染)人次。结果:2组治疗前检测生化指标比较,差异无显著性意义(P>0.05),治疗组治疗前后血清TP、PA、Alb和Hb比较,差异均有非常显著性意义(P<0.01);2组治疗后血清TP、PA、Alb和Hb比较,差异均有非常显著性意义(P<0.01)。治疗组治疗前后血清IgG、IgA和Kt/V值比较,差异有显著性或非常显著性意义(P<0.05,P<0.01);2组治疗后血清IgG、IgA和Kt/V值比较,差异有显著性或非常显著性意义(P<0.05,P<0.01)。治疗组腹膜透析相关感染发生率低于对照组(P<0.05)。结论:人工虫草制剂长期应用能明显改善CAPD患者临床症状,降低感染发生率,其机理与虫草制剂能调节机体免疫功能,改善患者营养状况及提高腹膜透析充分性有一定的关系。

Effect of Cordyceps Preparation on Continuous Ambulatory Peritoneal Dialysis(CAPD): An Observation of 34 Patients

Objective:To observe the effect of Artificial Cordyceps Preparation(ACP) on clinical symptoms,biochemical indexes,immunological indexes and urea clearance index(Kt/V) in the treatment of continuous ambulatory peritoneal dialysis(CAPD) patients.Methods:Sixty-seven CAPD patients were randomized into control group(N=33) and treatment group(N=34).The two groups were given treatment of CAPD,and the treatment group was treated with oral use of ACP.The course of treatment lasted six months.The changes of serum total protein(TP),albumin(Alb),prealbumin(PA),hemoglobin(Hb),immunoglobulin A(IgA),IgG,IgM and urea clearance index were observed before and after treatment in both groups.Meanwhile the incidences of peritonitis and tunnel infestation in both groups were observed.Results:The differences of biochemical indexes were insignificant between the both groups before treatment(P > 0.05).After treatment,serum levels of TP,PA,Alb and Hb in the treatment group differed from those before treatment(P < 0.01),and the differences were significant between the two groups after treatment(P < 0.01).Serum IgG,IgA and Kt/V in the treatment group after treatment differed from those before treatment,and the differences were significant between the two groups after treatment(P < 0.05 or P < 0.01).The incidences of peritonitis and tunnel infestation in the treatment group were obviously lower than those in the control group(P < 0.05).Conclusion:Long-term application of Artificial Cordyceps Preparation could markedly relieve the clinical symptoms,reduce the infection rates in CAPD patients,and the therapeutic mechanism is possibly correlated with the regulation of immune function and with the improvement of nutritional status and peritoneal dialysis sufficiency in CAPD patients.