| 银屑平颗粒对豚鼠银屑病动物模型的影响 |
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| 引用本文： | 李涛,李洪梅,李小芹,孙建辉,邱翔燕,周爱香.银屑平颗粒对豚鼠银屑病动物模型的影响[J].中国实验方剂学杂志,2010,16(16):137-139. |
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| 作者姓名： | 李涛 李洪梅 李小芹 孙建辉 邱翔燕 周爱香 |
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| 作者单位： | 1. 中国中医科学院中药研究所,北京,100700;江西中医学院,南昌,330004
2. 中国中医科学院中药研究所,北京,100700 |
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| 基金项目： | 科技部科研院所技术开发专项基金 |
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| 摘 要： | 目的:研究银屑平颗粒对豚鼠银屑病模型的影响。方法:采用心得安乳剂涂抹耳造豚鼠银屑病样模型,银屑平高、中、低剂量ig 2周,处死豚鼠,采用ELISA试剂盒检测豚鼠耳匀浆液中肿瘤坏死因子-α(TNF-α)及细胞间黏附因子(ICAM-1)的含量,并观察其对病理形态学的影响。结果:与正常组比较,模型组豚鼠TNF-α及ICAM-1显著升高(P0.05),与模型组比较,银屑平颗粒高、中剂量组、甲氨喋呤组TNF-α及ICAM-1显著降低(P0.01);与模型组比较,银屑平高、中、低剂量组对心得安所致的表皮皮损、红肿,皮肤糜烂,角化不全,毛细血管增生扩张等形态学改变有不同程度的改善。结论:银屑平颗粒对银屑病有良好的治疗作用。
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| 关 键 词： | 银屑病 豚鼠 银屑平颗粒 心得安 |
| 收稿时间： | 2010/7/12 0:00:00 |
Effect of Yinxieping Granules on Guinea Pig Model of Psoriasis |
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| LI Tao,LI Hong-mei,LI Xiao-qin,SUN Jian-hui,QIU Xiang-yan and ZHOU Ai-xiang.Effect of Yinxieping Granules on Guinea Pig Model of Psoriasis[J].China Journal of Experimental Traditional Medical Formulae,2010,16(16):137-139. |
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| Authors: | LI Tao LI Hong-mei LI Xiao-qin SUN Jian-hui QIU Xiang-yan and ZHOU Ai-xiang |
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| Institution: | Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China |
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| Abstract: | |
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| Keywords: | psoriasis guinea pig Yinxieping Granules propranolol |
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