| 肉桂水提物对正常大鼠尿液代谢物组的影响 |
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| 引用本文： | 张启云,李冰涛,徐国良,孙立波,汤喜兰,黄丽萍,余日跃,刘红宁.肉桂水提物对正常大鼠尿液代谢物组的影响[J].中国实验方剂学杂志,2010,16(17):164-168. |
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| 作者姓名： | 张启云 李冰涛 徐国良 孙立波 汤喜兰 黄丽萍 余日跃 刘红宁 |
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| 作者单位： | 1. 江西中医学院现代中药制剂教育部重点试验室,南昌,330006
2. 江西中医学院药学院,南昌,330006 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)基金项目(2006CB504702) |
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| 摘 要： | 目的:研究肉桂水提物对大鼠尿液中内源性代谢产物的影响。方法:肉桂水提物0.3 g·kg-1大鼠连续ig 30 d,收集0,1,8,15,22,29 d尿样,LC-MS/MS采集样品数据,经主成分分析(PCA),正交信号校正偏最小二乘法判别分析(OSC-PLS-DA)处理数据,结合生物标记物和相关资料,分析肉桂水提物对大鼠内源性代谢产物的影响。结果:肉桂水提物ig 8 d对大鼠尿液中内源性物质的影响最大。与空白组比较,给药组尿样中CPA18∶1(11Z)/0∶0],Gamma-linolenyl carnitine等物质浓度上升,Deoxyuridine,CerP(d18∶1/22∶0)等物质浓度降低。结论:肉桂水提物能显著影响大鼠体内与基础代谢和细胞信号相关物质的代谢。
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| 关 键 词： | 肉桂 代谢组学 生物标记物 |
| 收稿时间： | 4/6/2010 12:00:00 AM |
Metabomonics Study on Urine of Normal Rats Administered with Cinnamomi Cortex Water Extract |
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| ZHANG Qi-yun,LI Bing-tao,XU Guo-liang,SUN Li-bo,TANG Xi-lan,HUANG Li-ping,YU Ri-yue and LIU Hong-ning.Metabomonics Study on Urine of Normal Rats Administered with Cinnamomi Cortex Water Extract[J].China Journal of Experimental Traditional Medical Formulae,2010,16(17):164-168. |
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| Authors: | ZHANG Qi-yun LI Bing-tao XU Guo-liang SUN Li-bo TANG Xi-lan HUANG Li-ping YU Ri-yue and LIU Hong-ning |
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| Institution: | Key Laboratory of Modern Preparation, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;Key Laboratory of Modern Preparation, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;Key Laboratory of Modern Preparation, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;Key Laboratory of Modern Preparation, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;Key Laboratory of Modern Preparation, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China;Key Laboratory of Modern Preparation, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China |
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| Abstract: | |
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| Keywords: | Cinnamomi Cortex metabonomics biomarker |
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