通窍鼻炎颗粒联合针刺治疗过敏性鼻炎及对患者血清IL-4,IL-6及IL-10的影响

目的:探讨通窍鼻炎颗粒联合针刺治疗过敏性鼻炎(AR)疗效及对患者血清白细胞介素(IL)-4,IL-6,IL-10水平的影响。方法:110例符合纳入标准的AR患者随机分为对照组(n=55)和观察组(n=55)。常规治疗的基础上,对照组给予通窍鼻炎颗粒治疗,观察组在对照组治疗的基础上联合应用针刺治疗。观察比较两组临床疗效、临床症状积分及炎性因子IL-4,IL-6,IL-10水平。并随访6个月,比较两组患者复发率。结果:观察组的治疗总有效率为96.4%,明显高于对照组85.4%的总有效率(P0.05)。治疗后,与对照组相比,观察组喷嚏、流涕、鼻塞及鼻痒等症状积分显著降低,IL-4,IL-6,IL-10水平明显降低,比较都有统计学差异(均P0.05)。随访6个月,观察组的复发率为5.4%,明显低于对照组18.2%的复发率(P0.05)。结论:通窍鼻炎颗粒联合针刺治疗AR疗效可靠,能够显著提高临床疗效,改善临床症状,减轻炎性反应,且复发率低,临床上值得进一步研究。

Tongqiao Biyan Particles in Combination with Acupuncture in Treatment of Allergic Rhinitis and Level of Serum IL-4, IL-6, IL-10

Objective: The purpose of this study was to investigate the clinical effect of treatment of Tongqiao Biyan particles in combination with acupuncture in allergic rhinitis (AR), and its effects on levels of serum interleukin(IL) -4, IL-6, IL-10. Method: One hundred and ten cases of AR meeting the inclusion criteria were randomly divided into two groups equally. Besides conventional treatments, the control group was treated with Tongqiao Biyan particles, while the observation group was treated with Tongqiao Biyan particles and acupuncture. Then, the curative efficacy, clinical symptoms scores and inflammatory factors of IL-4, IL-6, IL-10 and recurrence rate were observed and compared. Result: The observation group had a total therapeutic efficiency of 96.4%, which was significantly higher than that 85.4% in the control group (P<0.05). In comparison with the control group, scores of sneeze, nasal mucus, nasal congestion and nasal itching in the observation were all statistically lower (all P<0.05). As to inflammatory factors, levels of IL-4, IL-6 and IL-10 in the observation group were statistically lower than those in the control group (all P<0.05). After the six-month follow-up, the recurrence rate in the observation group was 5.4%, which was statistically lower than 18.2% in the control group (P<0.05). Conclusion: Combined treatment of Tongqiao Biyan particles with acupuncture for AR is effective, which can significantly increase curative efficacy, improve clinical symptoms and alleviate inflammatory reaction with low recurrence rate.