复方黄芪颗粒对四氯化碳致大鼠慢性肝损伤的保护作用

目的：观察复方黄芪颗粒对四氯化碳（CCl4）慢性肝损伤的保护作用。方法：制备大鼠的CCl4慢性肝损伤模型，观察复方黄芪颗粒对慢性肝损伤大鼠血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总蛋白（TP）、白蛋白（ALB）、以及对肝组织羟脯氨酸含量等的影响。结果：复方黄芪颗粒在给药3个月后，低、中、高剂量组（1．9，3．8，7．6g／kg）均能降低血清ALT、AST的活力和肝组织羟脯氨酸的含量（P〈0．05或P〈0．001）。结论：复方黄芪颗粒能保肝降酶，对慢性肝损伤有明显的保护作用。

Protective Effects of Compound Astragali Granule against CCl_4-Induced Chronic Hepatic Injury in Rats

Objective:To examine the protective effect of compound astragali granule against CCl_4induced chronic hepatic injury in rats.Methods:CCl_4-induced chronic hepatic injury model was made in rats.Effects of compound astragali granule on biochemical indexes such as ALT,AST,TP,ALB in rat serum and hydroxyproline levels in liver tissue were observed.Results:after treated with compound astragali granule for three months,ALT and AST activities in serum and hydroxyproline levels in liver tissue decreased significantly in the three dosage groups of 1.9,3.8,7.6g/kg respectively(P<0.05,or P<0.001).Conclusion:Compound astragali granule could protect liver and decrease enzyme and had apparent protective effects against chronic hepatic injury.