稳心颗粒与普罗帕酮治疗早搏的疗效比较

目的:比较步长稳心颗粒与普罗帕酮治疗早搏的疗效及临床特点。方法:选择符合入选条件的过早搏动患者共107例(室上性早搏52例、室性早搏55例),完善静息12同步导联心电图,随机分为稳心颗粒组(W组,n=62)、普罗帕酮组(P组,n=45),W组给予稳心颗粒9 g,3次/d,口服;P组给予普罗帕酮150 mg,3次/d,口服。4周后,复查12导联同步心电图和24 h动态心电图,比较治疗前后早搏减少百分率、24 h平均心率、最慢心率及校正的QT间期离散度(QTcd)。结果:稳心颗粒治疗室上性早搏、室性早搏的有效率分别为73.53%,78.57%,总有效率75.81%,与普罗帕酮比较无统计学差异。稳心颗粒组治疗前后24 h平均心率降低不明显(77.67±5.86)bpm vs(77.42±4.99)bpm]、最慢心率降低不明显(60.89±5.40)bpm vs(60.55±4.71)bpm];普罗帕酮组治疗前后24 h平均心率明显降低(78.51±5.42)bpm vs(76.96±5.57)bpm,P<0.05]、最慢心率明显降低(61.31±5.69)bpm vs(58.53±4.80)bpm,P<0.05]。稳心颗粒能改善糖尿病、冠心病的QTcd。结论:步长稳心颗粒能有效减少早搏,不减慢治疗前后的24 h平均心率及最慢心率,能减小糖尿病、冠心病的QT离散度,适合心率较慢、糖尿病、冠心病患者合并早搏的治疗。

Comparison of Efficacy in Treatment of Premature Beat between Buchang Wenxin Granule and Propafenone

Objective: To compare the efficacy and clinical features of Buchang Wenxin granule and propafenone in the treatment of premature beat. Method: One hundred and seven patients with premature beats (supraventricular SV, n=52;ventricular V, n=55)randomly were divided into Wenxin granule group(W group, n=62)and propafenone group(P group, n=45),the patients in W group were given Buchang Wenxin Granule 9 g·d^-1, 3/d, the patients inP group were given propafenone 150 mg·d^-1, 3/d. 4 weeks later, all patients were evaluated by 12-lead simultaneous body surface electrocardiogram and 24 hours ambulatory Holter, respectively compares the percentage of reduced premature beat, 24 h average heart rate, the slowest heart rate, QTcd before and after treatment. Result: Wenxin Granule in therapeutic SV,V are respectively 73.53% and 78.57%, the total efficiency is 75.81%, have no significantly difference compared with propafenone; the 24 h average heart rate and the slowest heart rate of W group had not decreased significantly before and after treatment(77.67±5.86) bpm vs (77.42±4.99) bpm, (60.89±5.40) bpm vs (60.55±4.71) bpm; while P group had decreased significantly before and after treatment(78.51±5.42) bpm vs (76.96±5.57) bpm (P<0.05),(61.31±5.69) bpm vs (58.53±4.80) bpm (P<0.05). Wenxin rranule also can reduce the QTcd of patients with Diabetes mellitus(DM) and coronary heart disease(CHD). Conclusion: Buchang Wenxin granule is effective for treating premature beats, suitable for the patients with slower heart rate,DM,CHD.