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| 加水量与煎煮时间对葛根芩连汤主要成分溶出量的影响 | |
| 引用本文： | 张家成,章军,刘峰,穆兰澄,郭允,王跃生,仝小林.加水量与煎煮时间对葛根芩连汤主要成分溶出量的影响[J].中国实验方剂学杂志,2013,19(1):13-17. |
| 作者姓名： | 张家成 章军 刘峰 穆兰澄 郭允 王跃生 仝小林 |
| 作者单位： | 1. 中国中医科学院广安门医院,北京 100053;北京中医药大学,北京 100029 2. 中国中医科学院中药研究所,北京,100700 3. 中国中医科学院广安门医院,北京,100053 |
| 基金项目： | 国家重点基础研究发展"973"计划(2010CB530602) |
| 摘 要： | 目的:以葛根芩连汤为研究对象,对影响煎煮质量的加水量、煎煮时间等相关参数与主要成分溶出量之间的关系进行综合研究,得出葛根芩连汤的最佳煎煮工艺。方法:煎煮时间20,35,50,65,80 min;加水量6,9,12,15,18倍;煎煮次1次;用全面实验法,对以上参数进行排列组合确定煎煮工艺。每种工艺取选定葛根芩连汤加味方1剂煎煮3次。用HPLC测定煎煮液中主要成分含量,比较不同煎煮工艺对溶出量的影响。结果:①在相同煎煮时间、相同煎煮次数的条件下,主要成分的溶出量随着加水量的增多而呈现上升趋势。明显改变的点为9倍水时。②相同加水量、相同煎煮次数、不同煎煮时间,主要成分的溶出量随着煎煮时间的延长而呈现上升趋势。明显改变的点为50 min时。结论:确定葛根芩连汤煎煮最低加水量为9倍量,煎煮时间50 min。 |
| 关 键 词： | 葛根芩连汤 煎煮次数 加水量 煎煮时间 HPLC |
| 收稿时间： | 2011/11/10 0:00:00 |
Influence of Decocting Time and Water Amount on Dissolution of Main Ingredients from Gegen Qinlian Decoction |
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| ZHANG Jia-cheng,ZHANG Jun,LIU Feng,MU Lan-cheng,GUO Yun,WANG Yue-sheng and TONG Xiao-lin.Influence of Decocting Time and Water Amount on Dissolution of Main Ingredients from Gegen Qinlian Decoction[J].China Journal of Experimental Traditional Medical Formulae,2013,19(1):13-17. | |
| Authors: | ZHANG Jia-cheng ZHANG Jun LIU Feng MU Lan-cheng GUO Yun WANG Yue-sheng and TONG Xiao-lin |
| Institution: | Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;Beijing University of Chinese Medicine, Beijing 100029, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China |
| Abstract: | |
| Keywords: | Gegen Qinlian decoction decocting times water amount decocting time HPLC |
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