经皮给药系统促透方法及其联用研究进展

查阅近年来国内外有关经皮给药系统的文献，介绍纳米载体和物理促透法的作用机制，及各种促透方法联用研究进展。透皮促透方法在经皮给药系统中的应用，改善了药物的皮肤渗透性差，克服了皮肤角质层屏障等问题。而且几种促透方法联用可发挥协同作用使促透效果更佳，推动了经皮给药系统的发展。经皮给药系统具有无首过效应、血药浓度稳定、毒副作用小等优点。近年来多种促透新方法和新技术被用于经皮给药系统，提高药物的渗透能力，使得大部分药物经皮制剂的开发成为可能，今后应加强对透皮促透方法联用及其作用机制的研究，有望推动经皮给药制剂的发展。

Research Progress on Penetration Methods and its Combination of Transdermal Drug Delivery System

This paper discusses the penetration methods and its combination research progress of transdermal drug delivery system. Search the recent years domestic and foreign literature on TDDS, the penetration mechanism of Nano drug carrier systems, physical methods and the combination research progress are introduced in this paper. The use of transdermal penetration methods in TDDS, improve the poor skin permeability of the drug and overcome the problems of the skin stratum corneum barrier. Furthermore,the combinations of several methods is much better than any other one, promote the development of TDDS. TDDS has the advantage of no first-pass effect, stable plasma concentration and little drug side effects. In recent years, a variety of new methods and technologies had been used in TDDS to enhance drug penetration, making it becomes possible that the majority of drug to develop transdermal formulations, the research of transdermal penetration methods combination and its mechanism should be strengthened in future,expecting to promote the development of transdermal formulations.