| 狗脊毛甲醇提取物UPLC/Q-TOF-MS分析 |
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| 引用本文： | 徐钢,孙娜,赵敏杰,林桂梅,高慧,贾天柱.狗脊毛甲醇提取物UPLC/Q-TOF-MS分析[J].中国实验方剂学杂志,2014,20(7):46-50. |
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| 作者姓名： | 徐钢 孙娜 赵敏杰 林桂梅 高慧 贾天柱 |
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| 作者单位： | 辽宁中医药大学药学院, 国家中医药管理局中药炮制重点研究室, 辽宁省中药炮制工程技术研究中心, 辽宁 大连 116600;辽宁中医药大学药学院, 国家中医药管理局中药炮制重点研究室, 辽宁省中药炮制工程技术研究中心, 辽宁 大连 116600;辽宁中医药大学药学院, 国家中医药管理局中药炮制重点研究室, 辽宁省中药炮制工程技术研究中心, 辽宁 大连 116600;辽宁中医药大学药学院, 国家中医药管理局中药炮制重点研究室, 辽宁省中药炮制工程技术研究中心, 辽宁 大连 116600;辽宁中医药大学药学院, 国家中医药管理局中药炮制重点研究室, 辽宁省中药炮制工程技术研究中心, 辽宁 大连 116600;辽宁中医药大学药学院, 国家中医药管理局中药炮制重点研究室, 辽宁省中药炮制工程技术研究中心, 辽宁 大连 116600 |
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| 基金项目： | 国家自然科学基金项目（30973938） |
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| 摘 要： | 目的：探索狗脊毛化学成分组成及其外用止血的物质基础。方法：采用超声、索氏、回流3种方式对狗脊毛进行甲醇提取，通过UPLC/Q-TOF-MS对各提取物进行定性分析，流动相乙腈（A）-水（B）梯度洗脱（0~5 min，5%~55% A；5~7 min，55%~85% A；7~15 min，85%~100% A；15~20 min，100% A），检测波长254 nm，m/z扫描范围100~1 000，脱溶剂气温度350 ℃，脱溶剂气体积流量9 L·min-1，喷雾器压力2.4×105Pa，毛细管电压4 000 V。结果：3种方式共检出化合物50个，给出了其中38个化合物的推荐分子式和名称。编号32~39共8个化合物为一系列三酰基甘油类同系物。结论：狗脊毛中化合物包括植物油类（三酰基甘油）、有机酸类、有机酸酯类、生物碱类、黄酮类、多酚类、糖苷类等，相对分子质量集中于200~800，三酰基甘油可能为主要药效成分。
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| 关 键 词： | 狗脊毛 甲醇提取物 三酰基甘油 超高效液相-四级杆-飞行时间串联质谱 定性分析 |
| 收稿时间： | 2013/7/19 0:00:00 |
Analysis of Chemical Composition in Methanol Extract of Yellow Hairs from Rhizome of Cibotii Rhizoma by UPLC/Q-TOF-MS |
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| XU Gang,SUN N,ZHAO Min-jie,LIN Gui-mei,GAO Hui and JIA Tian-zhu.Analysis of Chemical Composition in Methanol Extract of Yellow Hairs from Rhizome of Cibotii Rhizoma by UPLC/Q-TOF-MS[J].China Journal of Experimental Traditional Medical Formulae,2014,20(7):46-50. |
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| Authors: | XU Gang SUN N ZHAO Min-jie LIN Gui-mei GAO Hui and JIA Tian-zhu |
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| Institution: | School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Key Laboratory of Chinese Materia Medica Processing, State Administration of Traditional Chinese Medicine of the People's Republic of China, Liaoning Engineering Research Center of Chinese Materia Medica Processing, Dalian 116600, China;School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Key Laboratory of Chinese Materia Medica Processing, State Administration of Traditional Chinese Medicine of the People's Republic of China, Liaoning Engineering Research Center of Chinese Materia Medica Processing, Dalian 116600, China;School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Key Laboratory of Chinese Materia Medica Processing, State Administration of Traditional Chinese Medicine of the People's Republic of China, Liaoning Engineering Research Center of Chinese Materia Medica Processing, Dalian 116600, China;School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Key Laboratory of Chinese Materia Medica Processing, State Administration of Traditional Chinese Medicine of the People's Republic of China, Liaoning Engineering Research Center of Chinese Materia Medica Processing, Dalian 116600, China;School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Key Laboratory of Chinese Materia Medica Processing, State Administration of Traditional Chinese Medicine of the People's Republic of China, Liaoning Engineering Research Center of Chinese Materia Medica Processing, Dalian 116600, China;School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Key Laboratory of Chinese Materia Medica Processing, State Administration of Traditional Chinese Medicine of the People's Republic of China, Liaoning Engineering Research Center of Chinese Materia Medica Processing, Dalian 116600, China |
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| Abstract: | |
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| Keywords: | yellow hairs of rhizome of Cibotii Rhizoma methanol extract triacylglycerols UPLC/Q-TOF-MS qualitative analysis |
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