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大鼠鼻炎模型的建立及通窍滴鼻液的治疗作用
引用本文:魏领地,苗培,马豹山.大鼠鼻炎模型的建立及通窍滴鼻液的治疗作用[J].中国实验方剂学杂志,1996,2(6):17-19.
作者姓名:魏领地  苗培  马豹山
作者单位:北京市药品检验所
摘    要:用临床分离的克雷伯氏肺炎杆菌感染大鼠鼻腔,造成鼻粘膜炎症。用2,4-硝基氯代苯丙酮液滴入大鼠鼻腔,造成大鼠鼻粘膜过敏性炎症。解剖可见明显病理改变。给予大剂量通窍滴鼻液可改善大鼠鼻炎症状,病理指标比模型组有较大改善。

关 键 词:鼻炎模型,通窍滴鼻液,鼻粘膜组织
收稿时间:1996/3/15 0:00:00

Establishing pathological Model of Rhinitis in Rats and Effect of Tongqiao Nasal Drops on It
Wei Lingdi,Miao Pei,Ma Baoshan.Establishing pathological Model of Rhinitis in Rats and Effect of Tongqiao Nasal Drops on It[J].China Journal of Experimental Traditional Medical Formulae,1996,2(6):17-19.
Authors:Wei Lingdi  Miao Pei  Ma Baoshan
Institution:Beijing Municipal Institute of Drug Control 100035
Abstract:A mucosa inflammation model was set up by either infecting Klebsiella pneumonia or dribbling 2,4-chloronitrobenzene in rat's nasal cavity. Pathological examination confirmed that nasal vestibule appeared to be hyperplasia of squamous epithelium,increase of columnar epithelium and goblet cells ,hemorrhage of mucosa epiderm and leukocyte migration. Tongqiao nasal drops at a high does can improve the syndrome of rat's rhinitis. Pathological changes above mentioned were greatly improved compared with the control groups.
Keywords:rhinitis model  Tongqiao nasal drops  nasal mucosa tissues  
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