首页 | 本学科首页   官方微博 | 高级检索  
检索        

温胆汤对实验性大鼠血脂代谢紊乱的调节及机理研究
引用本文:武晓宇,王燕,马伯艳,张福利.温胆汤对实验性大鼠血脂代谢紊乱的调节及机理研究[J].中国实验方剂学杂志,2007,13(7):44-46.
作者姓名:武晓宇  王燕  马伯艳  张福利
作者单位:黑龙江中医药大学,黑龙江,哈尔滨,150040
基金项目:哈尔滨市科委青年基金项目(2004AFQXT019)
摘    要:目的:研究温胆汤对血脂代谢紊乱大鼠的调节作用及其作用机理。方法:采用高脂乳剂灌饲法建立脂代谢紊乱大鼠模型,观察温胆汤对大鼠血脂(TC、TG)水平,丙二醛(MDA)含量,超氧化物歧化酶(SOD)活力,总脂解酶(LA),脂蛋白脂酶(LPL),肝脂酶(HL)活性的影响。结果:与模型对照组比较,温胆汤能降低实验性脂代谢紊乱大鼠血中的TC.TG水平,(分别P〈0.01和P〈0.05),提高血清SOD活性,降低MDA含量,(分别P〈0.05和P〈0.01),同时,温胆汤能提高肝脏LA和LPL活性,(P〈0.01),但对HL活性影响不明显。结论:温胆汤能有效调节机体脂质代谢,其机理可能是通过提高LA和LPL的活性而发挥其调脂作用,同时,温胆汤能有效降低机体内脂质过氧化程度,降低细胞受损程度。

关 键 词:温胆汤  血脂代谢紊乱  代谢综合征  调节
文章编号:1005-9903(2007)07-0044-03
收稿时间:2006-11-30
修稿时间:2006-11-30

Study of the Regulating Effect and the Mechanism of Wendan Decoction on Disorder of Lipid Metabolism in Rat
WU Xiao-yu,WANG Yan,MA Bo-yan,ZHANG Fu-li.Study of the Regulating Effect and the Mechanism of Wendan Decoction on Disorder of Lipid Metabolism in Rat[J].China Journal of Experimental Traditional Medical Formulae,2007,13(7):44-46.
Authors:WU Xiao-yu  WANG Yan  MA Bo-yan  ZHANG Fu-li
Institution:Heilongfiang University of Chinese Medicine, Heilongjiang, Harbin 150040
Abstract:Objective:To study the regulating effect and the mechanism of Wendan decoction on disorder of lipid metabolism in rat.Methods:The model rats of disorder of lipid metabolism have been established by feeding high-fat emulsion Ocally.The regulating effects of Wendan decoction on triglyceride(TG),total cholesterol(TG),super oxide dismutase(SOD),malondialdehyde(MDA),lipoprotein lipase(LPL),hepatic lipase(HL), total lipase(LA) in serum of the rats were observered.Result:Wendan decoction reduced the levels of TC,TG of the modal rats,compared with the model group the differences are P<0.01 and P<0.05.Wendan decoction raised SOD and reduced MDA,P<0.05 and P<0.01.At the same time,Wendan decoction could raise the activity of LA and LPL,P<0.01.but there was no effect on HL.Conclusion:Wendan decoction can regulate the disorder of lipid metabolism by raising the activity of LA and LPL in the modal rats effectively,and it may reduce the degree of lipid peroxidation and cell damage.
Keywords:Wendan decoction  lipid metabolism disorder  metabolism syndrome  regulation
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《中国实验方剂学杂志》浏览原始摘要信息
点击此处可从《中国实验方剂学杂志》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号