复明胶囊治疗干性年龄相关性黄斑变性64眼疗效观察

目的:观察复明胶囊治疗干性年龄相关性黄斑变性(AMD)(肝肾阴虚证)的临床疗效.方法:64例干性AMD患者随机分为对照组和观察组各32例(64眼).对照组给予口服明目地黄丸治疗,8 ～10粒/次,3次/d;观察组给予口服复明胶囊治疗,5粒/次,3次/d.两组疗程均为12周.观察治疗前后视力、中心视野、眼底玻璃膜疣面积、肝肾阴虚证及生活质量情况.结果:观察组总有效率为71.87％,优于对照组的51.56％ (P ＜0.01)；观察组患者视力改善、中心暗点分布改善均优于对照组(P＜0.05)；治疗后观察组玻璃膜疣面积小于对照组(P＜0.01)；观察组患者视物模糊、视物变形、眼干涩等主要症状评分及肝肾阴虚证总积分均低于对照组(P＜0.01)；治疗后观察组患者生活质量提高优于对照组(P＜0.01).结论:复明胶囊能改善干性AMD(肝肾阴虚证)患者的临床症状,提高视力、改善视野,提升患者生活质量,疗效明显,值得临床使用.

Fuming Capsule of Dry From Agerelated Macular Degeneration Treated With 64 Eyes

Objective: To observe the clinical curative effect of Fuming capsule in the treatment of liver and kidney yin deficiency of dry from agerelated macular degeneration(AMD). Method: Sixty-four patients of dry AMD were randomly allocated into control group and experimental group, 32 patients (64 eyes)in each group. In the control group, Mingmu Dihuang pills, 8 to 10 pills/time, 3 times/d, were oral administrated while in the experimental group, fuming capsule, 5 capsules/time, 3 times/d, oral taken. Both groups were treated for 12 weeks. The visual acuity, central visual field, retinal drusen area, the liver and kidney yin deficiency syndrome and life quality before and after the treatment were measured. Result: The total effectiveness of experimental group was 71.87%, better than that of the control group with 51.56% (P<0.01);the improvement of visual acuity and central scotoma distribution in the experimental group was better than that in the control group (P<0.05); drusen area of the experimental group was smaller than that of the control group (P<0.01) after treatment; scores to measure the symptoms of blurred vision, metamorphopsia, dry eyes along with liver and kidney yin deficiency syndrome scales of the experimental group were lower than the control group (P<0.01);the living quality of the experimental group was better than that of the control group (P<0.01). Conclusion: Fuming capsule can improve the clinical symptoms, eyesight, vision and life quality of liver and kidney yin deficiency of dry AMD, its curative effect is obvious so that it is worthy of clinical use.