| 青蒿总香豆素抗热应激作用及其机理的研究 |
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| 引用本文： | 闫寒,李爱媛,赵一,林启云,李沧海.青蒿总香豆素抗热应激作用及其机理的研究[J].中国实验方剂学杂志,2009,15(12):98-100. |
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| 作者姓名： | 闫寒 李爱媛 赵一 林启云 李沧海 |
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| 作者单位： | 1. 中国中医科学院医学实验中心,北京,100700
2. 广西中医学院,广西南宁,530001 |
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| 基金项目： | 国家重点基础研究发展规划(973计划)，北京市自然科学基金 |
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| 摘 要： | 目的:研究青蒿抗热应激作用及其机理。方法:利用高温高湿环境造成家兔热应激模型,观察青蒿总香豆素对家兔肛温上升及血液、肺组织磷脂酶A2活性和循环内皮细胞数目的变化,并测定其对脑、心脏、肾组织钠泵活性及小鼠抗脑缺氧能力的影响。结果:青蒿总香豆素可明显降低热应激家兔体温上升速度,并伴随血清、肺组织磷脂酶A2活性降低,循环内皮细胞减少,显著抑制脑、心、肾组织钠泵活性,延长断头小鼠张口喘气时间几近1倍。结论:香豆素部位可能是青蒿祛暑功效的活性成分群之一。
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| 关 键 词： | 黄花蒿 香豆素 热应激 磷脂酶A2 钠泵 循环内皮细胞 |
| 收稿时间： | 2009/8/21 0:00:00 |
Studies on Anti-heat-stress Activity and Its Mechanisms of Total Coumarins from Artemisia annua |
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| YAN Han,LI Ai-yuan,ZHAO Yi,LIN Qi-yun,LI Cang-hai.Studies on Anti-heat-stress Activity and Its Mechanisms of Total Coumarins from Artemisia annua[J].China Journal of Experimental Traditional Medical Formulae,2009,15(12):98-100. |
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| Authors: | YAN Han LI Ai-yuan ZHAO Yi LIN Qi-yun LI Cang-hai |
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| Institution: | 1.Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China;2.Guangxi Traditional Chinese Medical University,Nanning 530001,China |
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| Abstract: | Objective:To study the Anti-heat-stress activity and related mechanisms of total coumarins(TCs)from Artemisia annua.Methods: Heat stress rabbit model caused by high temperature and high humidity was used and rectal temperature(Tr) responses,PLA2 activity in blood and lung,circulating endothelial cells(CECs) were measured,moreover,Na+,K+-ATPase activity in brain,kedney and heart in rabbits was assayed,gasping time after decapitation in mice was observed after treatment of total coumarins(TCs) from Artemisia annua.Results: Administration of TCs reduced the rise of rectal temperature and CECs in heat stress rabbits,inhibited the activity of the PLA2 and Na+,K+-ATPase,increased the gasping time in mice.Conclusion: Coumarins are one of anti-heat-stress active fractions in Artemisia annua. |
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| Keywords: | Artemisia annua L coumarins heat stress phosphatidase A2 Na+ K+-ATPase Circulating endothelial cells |
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