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参麦注射液治疗癌因性疲乏86例
引用本文:梁健,许东升,韦袆.参麦注射液治疗癌因性疲乏86例[J].中国实验方剂学杂志,2012,18(17):279-281.
作者姓名:梁健  许东升  韦袆
作者单位:1. 三亚市人民医院,海南三亚,572000
2. 河南中医学院,郑州,450008
3. 海南医学院中医学院,海口,571199
基金项目:海南省教育厅2012年度海南省高等学校科学研究项目(HjkJ2012-38)
摘    要:目的:探讨参麦注射液对癌因性疲乏(CRF)的临床疗效及作用机制.方法:将156例CRF患者,分为观察组86例,对照组70例.观察组采用参麦注射液加常规对症治疗,对照组仅用常规对症治疗.疗程4周.评价Piper疲乏修订量表( RPFS-CV)、生活质量量表、中医证候积分及检测免疫功能等指标.结果:观察组RPFS-CV评分优于对照组(P<0.01);观察组躯体功能、情绪功能、社会功能评分及总评分均高于对照组(P<0.01);观察组免疫球蛋白G,A,M( IgG,IgA,IgM)水平高于对照组,自细胞介素-1( IL-1),肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05,P<0.01);观察组气阴两虚证积分低于对照组(P<0.01).结论:参麦注射液能改善CRF免疫功能,降低中医证候积分,从而有效减轻CRF,提高患者的生活质量.

关 键 词:参麦注射液  癌因性疲乏  生活质量
收稿时间:2012/3/28 0:00:00

Clinical Observation of Shenmai Injection Treatment for Cancer Related Fatigue
LIANG Jian,XU Dong-shen and WEI Yi.Clinical Observation of Shenmai Injection Treatment for Cancer Related Fatigue[J].China Journal of Experimental Traditional Medical Formulae,2012,18(17):279-281.
Authors:LIANG Jian  XU Dong-shen and WEI Yi
Institution:Department of Pharmacy, Sanya City People's Hospital, Sanya 572000, China;Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China;Hainan Medical College, Haikou 571199, China
Abstract:Objective:To investigate the clinical efficacy and mechanism of action of Shenmai injection for cancer related fatigue(CRF),Method: According to the clinical application of Shenmai injection,one hundred and fifty-six patients with CRF were divided into 86 cases of the observation group and 70 cases of the control group.The control group was treated by only conventional symptomatic treatment,while the observation group was treated by Shenmai injection in addition to conventional symptomatic treatment.The treatment in two groups lasted for 4 weeks.Piper fatigue revised scale,the indicators of quality of life scale,the syndrome score in traditional Chinese medicine and the immune function were evaluated.Result: The observation group showed a decrease in the number of CRF patients compared with the control group(P<0.01).The physical function,emotional function,social function and total score ratings in observation group were better than those in the control group(P<0.01).In observation group,levels of IgG,IgA,and IgM were higher than those in the control group,levels of IL-1 and TNF-α is were lower than those in the control group(P<0.05,P<0.01).The score of deficiency of qi and yin in the observation group was lower than that in the control group(P<0.01).Conclusion: Shenmai injection can improve immune function and reduce the score of deficiency of qi and yin,therefore it alleviates CRF and improve the quality of life.
Keywords:Shenmai injection  cancer related fatigue  quality of life
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