鲜地黄配方颗粒成型工艺优选

目的:探讨鲜地黄配方颗粒的成型工艺.方法:以制粒粒度、堆密度、流动性、溶化性、吸湿性为指标,考察不同辅料种类及辅料用量;以软材性状、制粒难易程度、成品性状为指标,考察不同体积分数乙醇,优选适宜润湿剂.结果:最佳制粒工艺为干燥粉与麦芽糊精按1:1比例混匀,以85％乙醇为润湿剂制软材,1号药筛挤压制粒,60℃干燥,整粒.成品颗粒的临界相对湿度60％.结论:该优选工艺方法简便易行,成品率高,为鲜地黄配方颗粒大生产提供实验依据.

Optimization of Molding Process for Fresh Rehmannia glutinosa Formula Granule

Objective:To investigate molding process of fresh Rehmannia glutinosa formula granule.Method:Kinds and consumption of accessories were investigated with particle size,bulk density,mobility,melting and moisture absorption as indexes;The concentrations of ethanol and optimum wetting agent were investigated with soft material properties,difficulty degree of granulation,product character as indicators.Result:Optimum granulation process was:mixing ratio of dry powder-maltodextrin 1 ∶ 1,85% ethanol as wetting agent to make soft material,extrusion granulation with one drug sieve,dried at 60 ℃,sorting particle.Critical relative humidity of product particles was 60%.Conclusion:This optimized process was simple with high yield,it could provide experimental basis for large-scale production of fresh R.glutinosa formula granule.