| 基于物质基础探讨中药"十八反"配伍致毒/增毒机制 |
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| 引用本文： | 宿树兰,段金廒,李文林,唐于平,范欣生.基于物质基础探讨中药"十八反"配伍致毒/增毒机制[J].中国实验方剂学杂志,2010,16(1):123-129. |
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| 作者姓名： | 宿树兰 段金廒 李文林 唐于平 范欣生 |
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| 作者单位： | 南京中医药大学,江苏省方剂研究重点实验室,江苏,南京,210046 |
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| 基金项目： | 国家自然科学基金,江苏省高校自然科学基金重大基础研究项目,江苏省高校青蓝工程科技创新团队建设项目资助(2006),江苏省自然科学基金,江苏省333高层次人才培养工程项目(2007) |
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| 摘 要： | 自金元时期以来,十八反一直是中药配伍禁忌理论的重要组成部分,随着人类对医疗健康的需求及现代认知水平的不断提高,中药配伍禁忌日益受到广泛关注,成为亟待解决的关键科学问题之一。该文对十八反配伍药对的物质基础研究现状进行分析归纳,从化学物质变化角度探讨十八反可能的致毒/增毒机制,以期为十八反配伍禁忌机制研究提供思考和借鉴,为临床应用提供参考。
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| 关 键 词： | 中药十八反 物质基础 毒性 |
| 收稿时间： | 2009/11/17 0:00:00 |
Exploration the Toxicity/Increase Virulence Mechanisms of "Eighteen Incompatible Medicaments" based on Chemical Substances |
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| SU Shu-lan,DUAN Jin-ao,LI Wen-lin,TANG Yu-ping and FAN Xin-sheng.Exploration the Toxicity/Increase Virulence Mechanisms of "Eighteen Incompatible Medicaments" based on Chemical Substances[J].China Journal of Experimental Traditional Medical Formulae,2010,16(1):123-129. |
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| Authors: | SU Shu-lan DUAN Jin-ao LI Wen-lin TANG Yu-ping and FAN Xin-sheng |
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| Institution: | Jiangsu Key laboratory for TCM formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046,China;Jiangsu Key laboratory for TCM formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046,China;Jiangsu Key laboratory for TCM formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046,China;Jiangsu Key laboratory for TCM formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046,China;Jiangsu Key laboratory for TCM formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046,China |
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| Abstract: | The "Eighteen Incompatible Medicaments" has been the important contents of incompatibility of Chinese herbs since JIN and YUAN dynasty. With the raising of medical treatment for human health and scientific cognition level, the incompatibility of Chinese herbs is an increasing concern and becomes a burning and crucial scientific question. This article analyzed the chemical components study situation of "Eighteen Incompatible Medicaments" and discussed the scientific nature based the toxic chemical components changes, mechanisms of action, and so on. These data may provide instructions for mechanism research of "Eighteen Incompatible Medicaments", supply some references for the rational application in clinic. |
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| Keywords: | Eighteen Incompatible Medicaments chemical compositions toxicity mechanism |
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