复方苦参注射液研究进展

通过查阅国内外文献开展中药大品种的技术改造,分类整理了近年来复方苦参注射液的化学成分、质量控制、药物代谢、药理活性和临床应用等方面的研究进展。该注射液主要含有氧化苦参碱、苦参碱、槐果碱、槐定碱和氧化槐果碱等生物碱类成分,具有抗肿瘤、镇痛、止血、抗应激、抗炎、提高免疫力等作用,多用于中晚期癌症(非小细胞肺癌、复发性肝癌、胃癌、肠癌等)和胸腔积液患者的辅助治疗。对其进行深入的研究以建立更加全面、合理的质量控制标准,有助于保证产品的一致性、有效性和安全性。

Advance in Study on Compound Kushen Injection

According to the literatures on the study of Compound Kushen Injection published in recent years. The advance on its chemical constituents, quality control , drug metabolism, pharmacological activities and clinical applications were summarized. The main constituents of Compound Kushen Injection are alkaloids, including oxymatrine and matrine, and the injection has the diverse activities of anti-tumor,analgesia and raising tumor patient's immunity. It was widely used for the adjuvant therapy of end-stage cancer. It should be further investigated for the quality consistency and the effectiveness as well as the safety of the product.