中药复方配伍的研究方法及其进展

中药复方是由2味或2味以上中药遵循中医理论组合而成的方剂。多味中药在合适的剂量配比之下,协同发挥作用,实现中医的整体调节治疗。研究中药复方的配伍对推动中药现代化发展、新药开发以及临床应用有着重要意义。近年来,研究者们在传统的"七情和合"与"君臣佐使"的基础上,运用新技术和新方法对中药复方的成分、药效活性和药代动力学性质等进行了研究,从不同角度探讨了中药复方配伍的科学内涵。同时,多种数理方法和模型的建立、网络药理学和数据挖掘方法的发展与应用,也对中药复方配伍研究提供了很大帮助。研究方法的发展虽促进了中药复方配伍的科学研究,但还需进一步建立适合中药复方配伍复杂关系的研究方法,以阐明中药复方及其成分/组分配伍的内在规律,进而构建新的现代中药复方,这也是目前中药复方配伍研究的重点任务。

Research Methods of Compatibility of Traditional Chinese Medicine Formulas and Its Advances

Traditional Chinese medicine formulas (TCMF) is composed of several Chinese herbal medicines based on the theory of TCM. It plays a synergistic role under the appropriate dosage ratio to achieve the overall adjustment and treatment of TCM. It is of great significance to study the compatibility of TCMF in promoting the modernization, development and clinical application of TCM. The compatibility law is the core of TCMF theory. In recent years, based on the seven compatible relations and monarch-minister-assistant-guide principles, the composition, pharmacological activity and pharmacokinetic properties of the TCMF and their compounds were studied by new techniques and new methods, and the scientific connotation of compatibility of TCMF was discussed from different perspectives. In addition, the establishment of a variety of mathematical methods and models, the development and application of network pharmacology and data mining methods also provide great help to the research on compatibility of TCMF. The development of research methods has promoted the scientific research on the compatibility of TCMF, but it is the main task of the research on the TCMF compatibility to establish the suitable research methods for the complex relationship of pharmacodynamic substances, to clarify the internal roles of TCMF and their compounds/components compatibility, and to construct a new modern TCMF.