益肾法对自发性高血压大鼠血压和肾血流影响的研究

目的:观察益肾法对自发性高血压大鼠(SHR)血压和肾脏血流的影响。方法:将16只SHR随机分为模型对照组,杞菊地黄丸组,二仙汤组和苯那普利组,连续灌胃给药6周。分别观测血压动态变化和肾血流情况。结果:滋阴补肾的杞菊地黄丸组和苯那普利组的收缩压低于模型对照组(P<0.05),其降血压作用强于温补肾阳的二仙汤;二仙汤组肾血流高于模型对照组(P<0.05),其对肾血流的改善作用强于杞菊地黄丸。结论:益肾中药可以降低SHR的收缩压,以滋阴补肾的杞菊地黄丸的降压作用更为显著。益肾中药可以改善SHR的肾血流量,以温补肾阳的二仙汤的作用更为显著。

Effect of Reinforcing Kidney on Blood Pressure and Kidney Blood Stream in SHR

Objective:To observe the effect of reinforcing kidney on the blood pressure and kidney blood stream in SHR.Method: Sixteen SHRs were randomly divided into model control group,Jijudihuang Pill group,Exian decoction group and benazepril group.The treatments were lasted for 6 weeks,and the dynamic blood pressure and kidney blood stream were investigated.Results:In the group of reinforcing kidney Yin(Jijudihuang Pill) and the benazepril group,systolic blood pressure was significantly lowed compared with the control(P<0.05).The effect of Jijudihuang Pill was stronger than that of the Erxian decoction for warming and invigorating kidney Yang.The kidney blood stream in Erxian decoction group was significantly higher than that in the controls(P<0.05),and also better than that in the Jijudihuang Pill.Conclusion:Reinforcing kidney may decrease blood pressure as indicated by the effect of Jijudihuang Pill.In addition,reinforcing kidney can improve kidney blood stream as evidenced by Erxian decoction in the SHRs.