生脉注射液对心衰大鼠地高辛组织浓度的影响

目的:了解生脉注射液对心衰大鼠地高辛组织浓度的影响.方法:40只心衰大鼠随机分为地高辛(对照)组及地高辛 生脉注射液低、中、高剂量(4mL/kg、8mL/kg、12mL/kg)组,用放射免疫(RIA)法测定不同时点大鼠心、肝、肾、骨骼肌中的地高辛浓度并进行比较.结果:4组大鼠心肌及肝脏中各时点地高辛浓度间无显著差异(P＞0.05);高剂量组30min、12h时点大鼠肾脏中地高辛浓度分别显著高于对照组、低剂量组及中剂量组(P＜0.05);中、高剂量组30min、高剂量组12h时点大鼠骨骼肌中地高辛浓度分别显著高于对照组、低剂量组(P＜0.05或P＜0.01).结论:高剂量生脉注射液有增加心衰大鼠肾脏及中、高剂量均有增加骨骼肌中地高辛浓度的趋势.

Influence of Shengmai Injection on the Tissue Concentration of Digoxin in Rats with Heart Failure

Objective:To study the influence of Shengmai Injection(SMI) on the tissue concentration of digoxin(DG) in rats with heart failure(HF).Methods:40 model rats with HF were randomly divided into 4 groups:the control group(treated with DG only) and other 3 groups(treated with DG plus SMI 4mL/kg,8mL/kg,12mL/kg respectively).The DG concentrations in the myocardium,liver,kidney and skeletal muscle were determined by radio immunoassay(RIA) at the designed time after administration.Result:There was no significant difference in the DG concentrations of myocardium and liver among 4 groups after administration.At the 30min and 12h after administration,the DG concentrations of kidney for the SMI 12mL/kg group were significantly higher than the other 3 ones respectively(P<0.05).The DG concentrations of the skeletal muscle in the SMI 8mL/kg and 12mL/kg groups at 30min and the SMI 12mL/kg at 12h were significantly higher than the control and SMI 20mL groups(P<0.05 or P<0.01).Conclusion:There was the tendency of the increased DG concentrations of kidney in the SMI 12mL/kg group and of skeletal muscle in the SMI 8mL/kg and 12mL/kg groups.