加味补阳还五汤对糖尿病心肌病患者BNP,CRP,HbA1c的影响

目的:探讨加味补阳还五汤对糖尿病心肌病(diabetic cardiomyopathy,DCM)患者血浆B型脑钠肽(brain natriuretic peptide,BNP)、C反应蛋白(C-reactive protein,CRP)及糖化血红蛋白(hemoglobin A1c,HbA1c)变化水平的影响.方法:研究对象分为糖尿病(diabetes mellitus,DM)对照组(30例)和DCM组(23例),DCM组在常规西药治疗的基础上加用加味补阳还五汤治疗3周,并测定治疗前后血浆BNP,CRP,HbA1c水平；结果:DCM组患者的BNP,CRP,HbA1c明显高于DM对照组(P＜0.05),DCM组应用加味补阳还五汤治疗后,BNP及CRP较治疗前下降(P＜0.05)；治疗前后HbA1c水平变化无 统计学意义(P＞0.05).结论:BNP与CRP水平升高能作为临床反映DCM病变严重程度的血清学指标,而加味补阳还五汤能降低其水平,显示其对DCM具有较好的疗效.

Effects of Jiawei Buyang Huanwu Decoction on Diabetic Cardiomyopathy Patients' BNP/CRP/HbA1c

Objective: To explore the effects of Jiawei Buyang Huanwu decoction on diabetic cardiomyopathy(DCM) patients' plasma B-type natriuretic peptide (BNP), C-reactive protein (CRP) and glycosylated hemoglobin (HbA1c) change levels. Method: The subjects were divided into diabetic control group (30 cases) and DCM group (23 cases). The DCM group, on the basis of conventional western medicine, plus Jiawei Buyang Huanwu decoction, after 3 weeks of treatment, and then measure the plasma BNP, CRP, and HbA1c level before and after treatment. Result: Diabetic cardiomyopathy patients' BNP, CRP and HbA1c significantly higher than that of the diabetic control group (P<0.05) and DCM group, after the treatment of Jiawei Buyang Huanwu decoction, BNP and CRP decreased (P<0.05) than before treatment, while the change of HbA1c level is not statistically significant before and after treatment. Conclusion: The higher levels of BNP and CRP can reflect the lesion severity of DCM as a clinical serological markers, while Jiawei Buyang Huanwu Decoction can reduce their levels, displaying its good effect on the treatment of DCM.