基于体内代谢-药效学相关性分析的 中药复方药效物质基础研究

中药复方药效物质基础研究是制约中药现代化、国际化的关键问题之一。近年来许多专家学者对此进行了大量研究与实践,尤其是中药血清药物化学研究方法受到了广泛关注,并取得了比较显著的成绩。作者对近5年来中药血清药物化学研究进行了简要介绍,并在前人研究基础上提出基于体内代谢-药效学相关性分析的中药复方药效物质基础研究方法,通过阐明药效与体内药物成分及代谢产物的定性定量关系,以姜黄胶囊为例,来揭示中药复方的药效物质基础。希望能够为中药复方药效物质基础研究扩展思路。

Research on Material Basis of Traditional Chinese Medicine Compound Based on Correlation Analysis of Metabolism and Efficacy

Systematic pharmacological evaluation of material basis for the efficacy of Chinese medicine compound is one of the key issues in modernization and internationalization of Chinese medicine. Many researchers have conducted a great deal of research and practice on it in recent years, especially the serum pharmaco-chemistry of traditional Chinese medicine(TCM) research methods attracted widespread attention and has made significant results. Studies on serum pharmaco-chemistry of TCM for the past five years were briefly reviewed. And this article proposes the research method of material basis of traditional Chinese medicine compound based on correlation analysis of metabolism and efficacy, through clarifying the efficacy and pharmaceutical ingredients and metabolites in vivo qualitative and quantitative relationships,case in Jianghuang capsule,to reveal the material basis for efficacy of Chinese medicine.We hope to extend the ideas of research on material basis of traditional Chinese medicine compound.