雷公藤减毒研究述评

雷公藤在风湿免疫性疾病与肾脏疾病的临床疗效显著,但其毒副作用限制了其在许多领域的应用。其毒副作用主要表现在消化、生殖、血液、免疫等系统。因此,雷公藤制剂的减毒持效研究成为近年的焦点。作者对1999～2011年雷公藤减毒研究的相关文献48篇进行了检索分析。由文献可知传统上的雷公藤减毒方法包括剂型改革、炮制及中药配伍等。近年来出现的双向固体发酵技术可获取雷公藤新药材,为雷公藤减毒持效研究拓宽了思路,值得进一步推广应用。今后需将传统中医理论与现代药理药效机制结合,借助于现代检测方法,揭示其减毒持效的机制,为雷公藤制剂的新药研发提供依据。

Review Research on Attenuating Toxicity of Chinese Herb Tripterygium wilfordii

The therapeutic effect of Chinese herb Triptergium wilfordii is significant and affirmative in immune rheumatic disease and renal diseases in clinical practice, but the toxicity limits its applications in many fields. Toxicity of T. wilfordii often bring damage to digestive system, reproductive system, hematological and immune system, so reducing toxicity but maintaining therapy effect has been focused on T. wilfordii studies in the past decade. Forty eight related articles on attenuating toxicity of Tripterygium from 1999 to 2011 have been searched and analyzed. In these literatures both traditional methods and Bi-directional solid fermentation technology can reduce the toxicity but maintaining therapy effect of Tripterygium. Traditional methods include formulation transform, processing, and combining with traditional Chinese medicine compounds. Advantage and disadvantage of each method on attenuating toxicity have been discussed. Bi-directional solid fermentation technology can provide new medicine and become new research approach. This technology is so promising and available, that it worth being further popularized. The mechanism of attenuating toxicity but maintaining therapy effect of Tripterygium will be disclosed with the aid of modern detection methods in order to pave the way on developing new medicine of Tripterygium preparation. By combining traditional Chinese medicine theory with modern pharmacology and Pharmacodynamics, more and more new methods for reducing toxicity but maintaining therapy effect of Tripterygium will be invented in years to come.