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| 保肾片治疗慢性肾功能衰竭气阴两虚兼湿浊证临床观察 | |
| 引用本文： | 柳于介,马芳玉,王亿平,徐锡兰,刘光珍,米彩云,何学红,王小琴,肖德才,张史昭,舒惠荃.保肾片治疗慢性肾功能衰竭气阴两虚兼湿浊证临床观察[J].中国实验方剂学杂志,2011,17(10):259-262. |
| 作者姓名： | 柳于介 马芳玉 王亿平 徐锡兰 刘光珍 米彩云 何学红 王小琴 肖德才 张史昭 舒惠荃 |
| 作者单位： | 1. 江苏康缘药业股份有限公司,江苏连云港,222001 2. 安徽中医学院附属医院,合肥,230031 3. 山东中医药大学附属医院,济南,250011 4. 山西省中医药研究院,太原,030012 5. 辽宁中医学院附属医院,沈阳,110032 6. 湖北中医学院附属医院,武汉,430061 7. 湖南省中医研究院,长沙,410006 8. 浙江中医学院附属医院,杭州,310006 9. 成都中医药大学附属医院,成都,610072 |
| 基金项目： | 国家科技部重大新药创制项目 |
| 摘 要： | 目的:观察保肾片对慢性肾功能衰竭(CRF)气阴两虚兼湿浊证的疗效。方法:采用多中心、随机、双盲双模拟、阳性药物平行对照方法,试验组345例患者服用保肾片加空白模拟片,对照组118例服用肾康宁片加空白模拟片。观察两组患者治疗前后中医证候积分值、尿素氮(BUN)、血肌酐(SCr)、内生肌酐清除率(CCr)、血红蛋白(Hb)、24 h尿蛋白定量变化情况。结果:试验组总有效率为88.12%,对照组总有效率为74.58%。试验组患者中医证候积分值、BUN,SCr,24 h尿蛋白定量均明显下降(P<0.05或P<0.01),CCr,Hb明显升高(P<0.01),对照组对BUN,SCr,Hb,24 h尿蛋白定量指标无明显改善。结论:保肾片可明显改善CRF气阴两虚兼湿浊证患者的临床表现,降低BUN,SCr水平,减少尿蛋白丢失,提高CCr,在一定程度上纠正患者的贫血状态。 |
| 关 键 词： | 慢性肾功能衰竭 气阴两虚兼湿浊证 保肾片 |
| 收稿时间： | 2011/3/22 0:00:00 |
Multi-center Randomized Double-blind Controlled Clinical Trial on Baoshen Tablets in Treatment of Chronic Renal Failure with Qi and Yin Deficiency and Dampness Syndrome |
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| LIU Yu-jie,MA Fang-yu,WANG Yi-ping,XU Xi-lan,LIU Guang-zhen,MI Cai-yun,HE Xue-hong,WANG Xiao-qin,XIAO De-cai,ZHANG Shi-zhao and SHU Hui-quan.Multi-center Randomized Double-blind Controlled Clinical Trial on Baoshen Tablets in Treatment of Chronic Renal Failure with Qi and Yin Deficiency and Dampness Syndrome[J].China Journal of Experimental Traditional Medical Formulae,2011,17(10):259-262. | |
| Authors: | LIU Yu-jie MA Fang-yu WANG Yi-ping XU Xi-lan LIU Guang-zhen MI Cai-yun HE Xue-hong WANG Xiao-qin XIAO De-cai ZHANG Shi-zhao and SHU Hui-quan |
| Institution: | Jiangsu Kanion Pharmaceutical Co.,Ltd.Lianyungang 222001, China;Jiangsu Kanion Pharmaceutical Co.,Ltd.Lianyungang 222001, China;Affiliated Hospital of Anhui College of TCM, Hefei 230031,China;Affiliated Hospital of Shandong University of TCM,Jinan 250011,China;Shanxi Provincial Research Institute of TCM, Taiyuan 030012,China;Shanxi Provincial Research Institute of TCM, Taiyuan 030012,China;Affiliated Hospital of Liaoning College of TCM, Shenyang 110032,Chian;Affiliated Hospital of Hubei College of TCM, Wuhan 430061,China;Hunan Provincial Research Institute of TCM,Changsha 410006, China;Affiliated Hospital of Zhejiang College of TCM, Hangzhou 310006, China;Affiliated Hospital of Chengdu University of TCM,Chengdu 610072,China |
| Abstract: | Objective:Observation the curative efficacy of Baoshen Tablets curing/therapy Chronic Renal Failure(CRF)with Qi and Yin Deficiency and dampness syndrome.Method: Using the methods of a multicenter,randomized,double-blind double-dummy,parallel control for positive drug,the experimental group 345 cases of patients taking Baoshen Tablets and imitated tablet,the control group of 118 patients taking Shenkangning Tablets and imitated tablet.Observing the changes before and after treatment by the value of TCM syndr... |
| Keywords: | Chronic renal failure Qi and Yin Deficiency and dampness syndrome Baoshen Tablets |
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