参芎化瘀胶囊对血管性痴呆模型大鼠学习记忆行为的作用

目的:观察参芎化瘀胶囊对血管性痴呆模型大鼠学习记忆行为的影响。方法:将60只健康SD大鼠随机分为正常组、假手术组、模型组、喜得镇0.6 mg·kg-1治疗组、复方丹参270 mg·kg-1治疗组和参芎化瘀胶囊480 mg·kg-1治疗组6个组。均ig给药,每日1次,术前预防给药7 d,术后继续给药28 d。采用反复夹闭、再通双侧颈总动脉同时ip硝普钠制备大鼠血管性痴呆模型,应用Morris水迷宫检测各组大鼠学习记忆行为。结果:与正常组及假手术组相比,模型组大鼠逃避潜伏期时间延长(P<0.01,P<0.01),撤走安全平台后穿越平台的次数及在原平台象限停留时间均减少(均P<0.01)。与模型组比较,各药物治疗组大鼠逃避潜伏期时间缩短(P<0.05,P<0.01),撤走安全平台后穿越平台的次数及在原平台象限停留时间均增多(均P<0.05)。参芎化瘀胶囊组大鼠逃避潜伏期时间较喜得镇组短(P<0.05),与复方丹参组之间差异无显著性。结论:参芎化瘀胶囊能改善血管性痴呆大鼠的学习记忆能力。

Shenxiong Huayu Capsule Improves Learning and Memory Behaviors in Rats with Vascular Dementia

Objective: To study the effects of Shenxiong Huayu Capsule on the learning and memory behaviors of rats with vascular dementia. Method: Sixty healthy rats were evenly divided into 6 groups: normal group, sham-operation group, model group, hydergine group, compound salvia miltiorrhiza tablet group and Shenxiong Huayu Capsule group. Vascular dementia (VD) model in rats was established by common carotid artery repeatedly occlusion and sodium nitroprusside ip injection. The learning and memory abilities of rats were detected by Morris water maze. Result: Compared with the normal group and sham-operation group, the escape latent period was increased in the model group(all P<0.01),and the times of traversing terrace and the period of staying in the pristine quadrant were obviously decreased in the model group after removing the terrace(all P<0.01). Compared with the model group,the escape latent period in the drug intervention groups was decreased(P<0.05,P<0.01),and the times of traversing terrace and the period of staying in the pristine quadrant were increased after removing the terrace(all P<0.05). The escape latent period in Shenxiong Huayu Capsule group was decreased compared with hydergine group(P<0.05), but there was no significant difference between Shenxiong Huayu Capsule group and compound salvia miltiorrhiza tablet group. Conclusion: Shenxiong Huayu Capsule can improve the abilities of learning and memory for the VD rats.