金水六君煎与三拗方合用辅助西药治疗慢性支气管炎急性加重期临床观察

目的:观察金水六君煎与三拗方合用辅助西药治疗慢性支气管炎急性加重期临床效果,并探讨其机制。方法:选取青海省中医院2012年5月—2014年5月收治的慢性支气管炎急性加重期患者160例,采用随机抽样方法分为对照组和治疗组,各80例。其中对照组患者采用常规西医干预治疗,治疗组患者则在此基础上加用金水六君煎合三拗方辅助治疗;比较两组患者临床疗效,临床症状体征持续时间,治疗前后中医证候积分、肺通气功能指标、炎性细胞因子水平及临床复发率等。结果:治疗组患者临床疗效明显优于对照组(P0.05);与治疗前比较,两组患者治疗后中医证候积分明显降低(P0.05),治疗后与对照组比较,治疗组患者中医证候积分明显降低(P0.05),治疗组患者临床症状体征持续时间明显短于对照组(P0.05)。与治疗前比较,两组患者治疗后肺通气功能指标水平明显增加(P0.05);治疗后与对照组比较,治疗组患者肺通气功能指标水平明显增加(P0.05)。与治疗前比较,两组患者治疗后炎性细胞因子水平明显降低(P0.05);治疗后与对照组比较,治疗组患者炎性细胞因子水平明显降低(P0.05)。治疗组患者临床复发率明显低于对照组(P0.05)。结论:金水六君煎与三拗方合用治疗慢性支气管炎急性加重期可有效改善临床症状体征,缩短病程,提高肺部功能,并有助于降低远期复发率。

Clinical Observation of Jinshui Liujun Jian and San'ao Fang in Assisting Western Medicine for Acute Exacerbation of Chronic Bronchitis

Objective: To investigate the clinical effects of Jinshui Liujun Jian and San''ao Fang in assisting the western medicine for acute exacerbation of chronic bronchitis. Method: The 160 patients with acute exacerbation of chronic bronchitis were chosen in the period from May 2012 to May 2014 in Qinghai Hospital of Traditional Chinese Medicine(TCM), and they were randomly divided into control group (80 patients) with routine western medicine intervention and treatment group (80 patients) with Jinshui Liujun Jian combined with San''ao Fang on the basis of control group treatment. The clinical efficacy, the duration time of clinical signs and symptoms, the TCM syndrome scores, pulmonary function levels, inflammatory cytokine levels and the clinical recurrence rate of two groups were compared. Result: The clinical efficacy in treatment group was significantly better than that in control group (P<0.05). The TCM syndrome scores were significantly reduced after treatment in both groups (P<0.05), and the scores in treatment group were significantly lower than those in control group after treatment (P<0.05). The duration time of clinical signs and symptoms of treatment group was significantly less than that in control group (P<0.05). The levels of pulmonary function were significantly increased after treatment in both groups (P<0.05), and the levels in treatment group were significantly higher than those in control group after treatment (P<0.05). The levels of inflammatory cytokine were significantly decreased after treatment in both groups (P<0.05), and the levels in treatment group were significantly lower than those in control group after treatment (P<0.05). The clinical recurrence rate in treatment group was significantly lower than that in control group (P<0.05). Conclusion: Jinshui Liujun Jian and San''ao Fang in assisting western medicine for acute exacerbation of chronic bronchitis can efficiently alleviate clinical symptoms and signs, shorten the clinical course, improve lung functions, and help to reduce the risk of long-term recurrence.