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包埋紫杉醇的Pluronic P85/聚乳酸纳米粒子制备及体外释放行为考察
引用本文:李资玲,熊向源,龚妍春,李玉萍.包埋紫杉醇的Pluronic P85/聚乳酸纳米粒子制备及体外释放行为考察[J].中国实验方剂学杂志,2014,20(1):1-4.
作者姓名:李资玲  熊向源  龚妍春  李玉萍
作者单位:江西科技师范大学生命科学学院, 南昌 330013;江西科技师范大学生命科学学院, 南昌 330013;江西科技师范大学生命科学学院, 南昌 330013;江西科技师范大学生命科学学院, 南昌 330013
基金项目:国家自然科学基金项目(21264009,81060264);江西省教育厅科学技术研究项目(GJJ10594);人事部留学人员科技活动项目([2010]412)
摘    要:目的:制备包埋紫杉醇的Pluronic P85/聚乳酸(PLA-P85-PLA)纳米粒子并考察其形态及体外释放行为。方法:采用本体聚合法合成PLA-P85-PLA嵌段共聚物,透析法制备PLA-P85-PLA纳米粒子,UV测定包封率及载药量,HPLC测定紫杉醇的体外释放行为,MTT测定纳米粒子的生物相容性。HPLC条件为流动相乙腈-PBS(50:50),检测波长227 nm。结果:包埋紫杉醇的PLA-P85-PLA纳米粒子粒径140 nm,包封率56%,载药量9.4%,体外释放在前20 h呈快速释放形式,接着在长达近4 d的时间内呈现缓慢释放,且仅约12%被包埋的紫杉醇释放出来,包埋紫杉醇的PLA-P85-PLA纳米粒子处理的OVCAR-3细胞存活率(41%)明显低于空白紫杉醇(70%)。结论:PLA-P85-PLA嵌段共聚物是良好的药物载体,可用于包埋疏水性强的抗癌药物。

关 键 词:紫杉醇  Pluronic  P85  纳米粒子  体外释放行为  高效液相色谱  细胞存活率  细胞毒性试验
收稿时间:6/9/2013 12:00:00 AM

Preparation and in vitro Release Behavior of Paclitaxel-Loaded Pluronic P85/Polylactic Acid Nanoparticles
LI Zi-ling,XIONG Xiang-yuan,GONG Yan-chun and LI Yu-ping.Preparation and in vitro Release Behavior of Paclitaxel-Loaded Pluronic P85/Polylactic Acid Nanoparticles[J].China Journal of Experimental Traditional Medical Formulae,2014,20(1):1-4.
Authors:LI Zi-ling  XIONG Xiang-yuan  GONG Yan-chun and LI Yu-ping
Institution:School of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, China;School of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, China;School of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, China;School of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, China
Abstract:Objective: To prepare paclitaxel-loaded Pluronic P85/polylactic acid(PLA-P85-PLA) nanoparcticles,then investigate its morphology and in vitro release behavior. Method: PLA-P85-PLA block copolymer was synthesized by bulk polymerization,PLA-P85-PLA nanoparcticles were prepared by dialysis method,encapsulation efficiency and drug loading capacity were determined by UV,in vitro release behavior of paclitaxel-loaded PLA-P85-PLA nanoparticles was determined by HPLC,biocompatibility of nanoparticles was measured by MTT.HPLC conditions were as follows: mobile phase of acetonitrile-PBS solution(50:50),detection wavelength at 227 nm. Result: Particles size of paclitaxel-loaded PLA-P85-PLA nonoparticles was 140 nm,encapsulation efficiency and drug loading capacity were 56% and 9.4%,respectively;In vitro release of these prepared nonoparticles in the first 20 h was a rapid release form,followed by a slow release form within nearly 4 d and only about 12% of entrapped paclitaxel released,cell survival rate of OVCAR-3 treated by paclitaxel-loaded PLA-P85-PLA nanoparcticles(41%) was lower than free paclitaxel(70%). Conclusion: PLA-P85-PLA block copolymer was a good drug carrier for embedding drug with low solubility.
Keywords:paclitaxel  Pluronic P85  nanoparticle  in vitro release behavior  HPLC  cell survival  cytotoxicity test
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