四磨汤治疗非胃肠术后胃肠功能障碍的Meta分析

运用Meta分析评价四磨汤治疗非胃肠术后胃肠功能障碍的临床疗效.电子检索维普、中国期刊全文数据库、万方数据库中1989-2011年发表的四磨汤治疗功能性消化不良的临床随机对照试验.按照Cochrane协作网的相关方法评价纳入文献质量和提取有效数据进行Meta分析.用Rev Man 4.2.7软件进行分析.共纳入44个研究,Meta分析结果提示,四磨汤可以显著提前非胃肠术后胃肠功能障碍患者的肛门排气时间,促进患者胃肠功能的恢复SMD=-2.25,95％ CI(-2.75,-1.74),P＜0.000 01]；四磨汤可以明显降低术后腹胀发生率OR=0.20,95％CI(0.13,0.30),P＜0.000 01];四磨汤可以提高剖宫产术后患者的泌乳量充足率OR =6.45,95％ CI(4.26,9.78),P＜0.000 01].未发现明显不良反应.现有的临床资料显示出四磨汤治疗非胃肠术后胃肠功能障碍疗效显著且安全性较高,但由于纳入文献质量较低且存在发表偏倚,其疗效尚需要设计严格的随机双盲试验予以证实.

Meta-analysis on Simotang in Gastrointestinal Dysfunction with No Gastrointestinal Surgery

To evaluate the clinical effect of simotang for gastrointestinal dysfunction with no gastrointestinal surgery.We searched CNKI,VIP,wanfang(1989—2011) to identify randomized controlled trials about simotang for gastrointestinal dysfunction patients with no gastrointestinal surgery.The methodological quality was assessed and the data was obtained according to the Cochrane Reviewer’s Handbook and related methods.Meta-analyses were performed using Rev Man 4.2.7 softwar.Forty-four eligible studies were included.The results of meta-analyses showed that simotang could shorten the anus exhaust time than the control group;Simotang can reduce the incidence of abdominal distension;Simotang can improve the adequacy of lactation than the control group.Find no adverse reaction.Comparied with the control group,simotang can improve the therapeutic effect on the patients whose gastrointestinal dysfunction with no gastrointestinal surgery and have high security.But because the literatures exist a low quality and partial,its curative effect still needs the strict,randomized,double-blind tests to be confirmed.