前列舒康胶囊对前列腺炎模型大鼠及前列腺组织形态的影响

目的 :考察前列舒康胶囊对消痔灵和大肠杆菌所致大鼠前列腺炎的影响。 方法 :采用文献方法造模,连续给药30 d后观察大鼠前列腺湿重、前列腺白细胞及卵磷脂小体密度,并进行统计学处理。 结果 : 前列舒康胶囊各剂量组可明显降低模型大鼠前列腺重量和白细胞数(P<0.01),中、高剂量组可回升低下的卵磷脂小体密度(P<0.05或P<0.01),明显降低大鼠前列腺组织中炎细胞浸润和成纤维细胞增生(P<0.05)。 结论 : 前列舒康胶囊可显著改善慢性前列腺炎病组织学的异常改变;对大肠杆菌所致细菌性前列腺炎具有显著的治疗作用。

Effect of Qianlieshukang Capsule on Pathomorphology of Prostate and the Tissues of Prostatitis in Model Rats

Objective: To investigate the effects of Qianlieshukang Capsule in treating prostatitis. Method : Pharmacological investigations were carried out to study the impact of Qianlieshukang Capsule on rat's prostate fribrosis inflammation caused by Xiaozhiling and on rat's prostatitis caused by E.coli. Results: Qianlieshukang Capsule has significant effect for treating prostatitis induced by Xiaozhiling and that induced by E.coli, indicated by prostate weight, leucocyte count and lecithin density(P<0.05 or P<0.01). Conclusions: Qianlieshukang Capsule can alleviate prostate pathological changes in chronic prostatitis, and is effective in treating bacterial prostatitis incause by E.coli.