中药制剂生物利用度研究概况

生物利用度是药物安全性及有效性的重要评价指标。通过检索万方、中国知网及OVI等数据库,对国内外近10年来150余篇相关资料进行全面的分析、整理和综述。从药物和生物两方面阐述了生物利用度的影响因素,包括剂型、理化性质、制剂工艺、胃肠道生理环境、给药时间及途径等。基于此从前体药物设计、胃内滞留释药系统、环糊精包合技术、固体分散技术、共研磨技术、纳米技术等制剂技术方面探讨改善中药制剂生物利用度的研究方法,以期为中药的现代化研究提供有意义的参考。

Research of Bioavailability of Chinese Materia Medica Preparation

Bioavailability was important evaluation index of safety and effectiveness of drugs.Consult data library such as Wan Fang, CNKI, OVI and so on, comprehensive analyzed and reviewed more than 150 related data recent 10 years from domestic and abroad. Summarized the influencing factors of bioavailability from two aspects of medicine and biology, consist of the form of drugs, physicochemical property, the preparation technology, physiological environment of gastrointestinal, the delivery time and way and so on. Some new research ideas like the pro-drug strategy, the gastro-retentive drug delivery system, cyclodextrin closure technology, solid dispersion technique, co-grinding technology, nano-technology etc. for improving bioavailability of traditional chinese medicine (TCM)preparations were discussed in order to provide reference for the research on modernization of TCM preparations.