葛根芩连汤直肠滴注联合推拿对湿热型腹泻小儿血清胃泌素、血浆胃动素及生长抑素水平的影响

目的:观察葛根芩连汤直肠滴注联合推拿对湿热型腹泻小儿血清胃泌素、血浆胃动素及生长抑素水平的影响,并探讨其作用机制。方法:选取天津中医药大学第一附属医院2013年8月—2016年10月收治的100例腹泻患儿,按随机数字表法分为治疗组(50例)和对照组(50例)。在给予常规西医对症处理及支持疗法的基础上,对照组患儿予以推拿手法,治疗组在对照组的基础上加用葛根芩连汤进行直肠滴注给药,连续治疗3 d后,对两组患儿临床疗效,退热、止泻、腹痛消退时间、纠正脱水及恢复进食时间,中医证候积分,以及血清胃泌素(GAS),血浆胃动素(MOT)及生长抑素(SS)水平进行比较。结果:治疗组患儿总有效率为94.00%,对照组为82.00%,治疗组优于对照组(P0.05);经治疗,治疗组患儿在退热、止泻、腹痛、纠正脱水及恢复进食时间方面明显短于对照组(P0.05);治疗后与治疗前比较,两组中医证候积分均有明显改善(P0.05),治疗组中医证候积分明显低于对照组(P0.05);治疗前两组GAS,MOT,SS水平比较均无显著性差异,通过治疗,两组患者GAS,MOT水平均明显降低,SS水平明显升高,治疗组效果明显优于对照组(P0.05)。结论:葛根芩连汤直肠滴注联合推拿疗法可以明显缓解湿热型腹泻患儿临床症状,缩短治疗时间,通过有效协调胃肠道激素因子的平衡,改善胃肠道功能。

Clinical Efficacy of Gegen Qinlian Tang for Rectoclysis Combined with Massage Manipulation on Gastrin, Motilin and Somatostatin of Children with Damp-heat Syndrome Diarrhea

Objective: To study the clinical efficacy of Gegen Qinlian Tang for rectoclysis combined with massage manipulation on gastrin, motilin and somatostatin of children with damp-heat syndrome diarrhea. Method: A total of 100 cases of children with diarrhea treated in our hospital from August 2013 to October 2016 were selected and divided into two groups according to the random number table, with 50 cases in clinical group and 50 in control group. In addition to the routine western treatment, the control group was also given massage manipulation, while the clinical group was additionally given Gegen Qinlian Tang for rectoclysis. Then, treatment effect, fever, diarrhea, abdominal pain disappeared time, correct dehydration and resumption of feeding time, traditional Chinese medicine (TCM) syndrome score, and values of gastrin (GAS), motilin (MOT) and somatostatin (SS) were compared after treatment for 3 days. Result: The total effective rate of the clinical group was 94.00%, which was higher than 82.00% in control group, with significant differences (P<0.05). Fever, diarrhea, abdominal pain disappeared time, correct dehydration and resumption of feeding time in clinical group were obviously shorter than those in control group (P<0.05). Compared with before treatment, TCM syndrome score of two groups was significantly improved after treatment, with statistically significant differences (P<0.05). Compared with control group, TCM syndrome score of the clinical group was lower, with statistically significant differences (P<0.05). Compared with before treatment, GAS and MOT of two groups decreased, while SS increased after treatment (P<0.05). Compared with control group, the levels of GAS and MOT in clinical group were lower, while SS was higher after treatment (P<0.05). Conclusion: Gegen Qinlian Tang for rectoclysis combined with massage manipulation can significantly alleviate the symptoms of damp-heat syndrome diarrhea in children, shorten the treatment time, and improve gastrointestinal function by effectively coordinating the balance of gastrointestinal hormones.