萆薢渗湿汤加味联合氟康唑治疗复杂型VVC的疗效及对阴道微生态的影响

目的:探讨萆薢渗湿汤加味联合氟康唑治疗复杂型外阴阴道假丝酵母菌病的疗效及对阴道微生态的影响.方法:将2010年6月至2011年12月符合纳入标准的复杂型外阴、阴道假丝酵母菌病(VVC)患者90例分成3组,每组30例.西药组(A组)口服氟康唑；中药组(B组)口服中药萆薢渗湿汤加味；中西药联合组(C组)氟康唑与中药联合应用.观察3组患者疗效及用药前后阴道微生态的变化,并随访治疗后的复发情况.结果:3组的治愈率、总有效率分别为A组73.3％,83.3％；B组6.7％,73.3％；C组93.3％,100％,C组分别与A,B组比较有差异性(P＜0.05)；A组与B组比较有差异性.A,C组的复发率分别为31.8％,3.6％,两组比较有显著性差异(P＜0.01).治疗前阴道微生态异常的发生率分别是A组83.3％、B组76.7％、C组73.3％,组间比较无差异性,治疗后分别为A组46.7％,B组16.7％,C组6.7％,与用药前比较有显著性差异,组间比较有差异性.结论:萆薢渗湿汤加味联合氟康唑治疗复杂性VVC疗效显著,复发率低,可明显改善患者的阴道微生态,减少复发.

Effect of Bixie Shenshi Decoction Combined with Fluconazole on Complex VVC and Vaginal Microbial Ecology

Objective:To explore effect of Bixie Shenshi decoction combined with fluconazole on the complex type of vulvovaginal candidiasis(VVC) and the vaginal microbial ecology. Method: Ninety cases which met the inclusion criteria of complex VVC between June 2010 to December 2011 were divided into three groups:Each group of 30 cases: Western medicine group (group A), oral fluconazole; traditional Chinese medicine group (group B),oral Bixie Shenshi decoction, combination of Chinese and Western medicine group(group C): application with Chinese medicine combined with fluconazole.Observe the therapeutic effect of three groups of patients and the vaginal microbial ecology changes before and after medication, and follow-up relapse after treatment. Result: The cure rate and total effective rate of three groups were as folloes:A group 73.3%, 83.3%;B group 6.7%, 73.3%;C group 93.3%,100%,group C was compared with group A and group B (P<0.05), group A and group B had differences.In group A and group C recurrence rate was 31.8% and 3.6%, respectively, the two groups had significant difference(P<0.01).Before treatment of vaginal microecological exception occurrence rate in group was A 83.3%, group B 76.7%, group C 73.3%,comparison between groups was no difference.In three groups othe microecological anomaly rate after treatment was as follows:group A 46.7%; group B 16.7%;group C 6.7%, and compared with before treatment there were significant differences. Conclusion : Bixie Shenshi decoction combined with fluconazole in treatment of complicated VVC has notable efficiency.