固本消瘤胶囊抑制小鼠Lewis肺癌生长及抗血管生成研究

目的 :探讨中药固本消瘤胶囊对小鼠Lewis肺癌抑瘤作用及机制。方法 :体内动物实验观察小鼠肿瘤生长 ;免疫组化染色S P法、病理彩色图像定量分析法检测小鼠肿瘤组织中微血管密度 (MVD)、血管内皮生长因子 (VEGF)表达。结果 :中药组、化疗组、中药加化疗组对小鼠Lewis肺癌抑制率分别为为 4 0 5 %、5 2 6 9%、6 1 0 9% ,与对照组比较有显著差异 (P <0 0 1)。中药组、中药加化疗组MVD、VEGF表达水平以及化疗组MVD水平明显下降。结论 :固本消瘤胶囊对小鼠Lewis肺癌有明显抑制作用 ,能够抗肿瘤新生血管生成

Inhibitory Effect and Antiangiogenesis of Gubenxiaoliu Capsule on Lewis Lung Carcinoma of Mouse

Objective:To explore the inhibitory effect of tumor growth and antiangiogenesis of Gubenxiaoliu capsule(GC) on Lewis lung carcinoma of mouse.Methods:In vivo animal experiment was used to investigate the growth of mouse tumor.Immunohistochemically(S P) and quantitative pathologic image analysis were used to investigate the microvesel dencity(MVD) and expression of vascular endothelial growth factor(VEGF) in tumor tissue.Results:The inhibitory rates on mouse tumor of GC group,Chemotherapy group and GC Chemotherapy group are 40 58%, 52 69%, 61 09% respectively,The inhibitory rates are significantly higher than the control,MVD and expression of VEGF of GC group and GC Chemotherapy group and MVD of Chemotherapy group decreased significantly.Conelusion:GC could inhibit the growth and angiogenesis of Lewis lung carcinoma of mouse.