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| 真武汤抗大鼠肾间质纤维化作用的研究 | |
| 引用本文： | 邱模炎,姜岳,赵宗江,李葆青,高杰东,申丽红,杨美娟,陈永德,郭洁,吴蔚.真武汤抗大鼠肾间质纤维化作用的研究[J].中国实验方剂学杂志,2010,16(17):177-180. |
| 作者姓名： | 邱模炎 姜岳 赵宗江 李葆青 高杰东 申丽红 杨美娟 陈永德 郭洁 吴蔚 |
| 作者单位： | 1. 中国中医科学院望京医院,北京,100102 2. 北京市朝阳区太阳宫社区卫生服务中心,北京,100028 3. 北京中医药大学,北京,100028 4. 福建省安溪县中医院,福建,安溪,362400 |
| 基金项目： | 人事部、国家中医药管理局留学回国人员科技活动择优资助项目 |
| 摘 要： | 目的:观察真武汤对肾间质纤维化大鼠的作用,并通过观察真武汤对肾脏Ⅰ,Ⅲ型胶原纤维的影响,探讨真武汤抗肾间质纤维化的作用机制。方法:采用"单肾切除加腺嘌呤灌胃法"建立大鼠慢性肾衰竭模型。治疗组予真武汤9.8,2.45g.kg-1 ig,对照组予尿毒清溶液ig。给药4周后处死大鼠取血测肌酐(Cr),尿素氮(BUN),钙(Ca2+)、磷(P3+),肾脏切片分别进行HE染色、PASM染色、Masson染色、Sirius Red染色、Mallory染色,光镜下观察大鼠肾组织的病理形态学改变,HE染色进行肾小管间质病变半定量分析,PASM染色、Masson染色、Sirius Red染色进行肾脏组织病理学图像分析。结果:在肾间质纤维化面积、肾小球系膜积分吸光度等方面,真武汤高、低剂量组的作用优于模型组和尿毒清组,P0.05。真武汤高、低剂量组在肾间质中Ⅰ,Ⅲ型胶原分布面积等方面的作用与模型组比,P0.05。结论:真武汤具有抗肾间质纤维化的作用,其作用途径可能与抑制Ⅰ,Ⅲ型胶原纤维增生有关。 |
| 关 键 词： | 真武汤 慢性肾衰竭 大鼠 肾间质纤维化 |
| 收稿时间： | 2010/9/27 0:00:00 |
Effect of Zhenwu Decoction on Renal Interstitial Fibrosis in Rats |
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| QIU Mo-yan,JIANG Yue,ZHAO Zong-Jiang,LI Bao-qing,GAO Jie-dong,SHEN Li-hong,YANG Mei-Juan,CHEN Yong-de,GUO Jie and WU Wei.Effect of Zhenwu Decoction on Renal Interstitial Fibrosis in Rats[J].China Journal of Experimental Traditional Medical Formulae,2010,16(17):177-180. | |
| Authors: | QIU Mo-yan JIANG Yue ZHAO Zong-Jiang LI Bao-qing GAO Jie-dong SHEN Li-hong YANG Mei-Juan CHEN Yong-de GUO Jie and WU Wei |
| Institution: | WangJing Hospital, China Academy of Chinese Medical Sciences, BeiJing 100102, China;Taiyanggong Health Service Center, BeiJing 100028, China;BeiJing University of Traditional Chinese Medicine, BeiJing 100028, China;WangJing Hospital, China Academy of Chinese Medical Sciences, BeiJing 100102, China;Anxi Hospital of Traditional Chinese Medicine, Anxi 362400, China;WangJing Hospital, China Academy of Chinese Medical Sciences, BeiJing 100102, China;BeiJing University of Traditional Chinese Medicine, BeiJing 100028, China;WangJing Hospital, China Academy of Chinese Medical Sciences, BeiJing 100102, China;WangJing Hospital, China Academy of Chinese Medical Sciences, BeiJing 100102, China;WangJing Hospital, China Academy of Chinese Medical Sciences, BeiJing 100102, China |
| Abstract: | |
| Keywords: | Zhenwu Decoction chronic renal failure rat renal interstitial fibrosis |
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