芪参益气滴丸对缺血性心肌病心力衰竭患者 心功能及NT-proBNP的影响

目的:观察芪参益气滴丸在缺血性心肌病心力衰竭治疗中的疗效及对左室功能、血浆N端脑钠肽前体(NT-proBNP)水平的影响.方法:80例符合缺血性心肌病心力衰竭诊断标准的患者,随机分为治疗组和对照组各40例,对照组采用常规西医治疗,治疗组在对照组治疗基础上加用芪参益气滴丸口服,观察两组治疗前及治疗后8周的心功能分级,6 min步行距离,心脏超声指标和NT-proBNP水平变化,评估其有效性.结果:治疗组较对照组能显著改善患者的左室功能并延长6 min步行距离(P＜0.05),显著降低血浆NT-proBNP水平,增加左心室射血分数(P＜0.05).结论:芪参益气滴丸可明显改善缺血性心肌病心力衰竭患者的心脏功能,提高运动耐量及生活质量,改善心室重构,不良反应少.

Effect of Qishen Yiqi Dripping Pills on Cardiac Function and Plasma NT-proBNP Level in Patients with Heart Failure Induced by Ischemic Cardiomyopathy

Objective: To observate the effect of Qishen Yiqi Dripping pills on cardiac function and levels of plasma NT-ProBNP level in patients with heart failure induced by ischemic cardiomyopathy. Method: Eighty patients with heart failure induced by ischemic cardiomyopathy were randomly divided into 2 groups, 40 patients in control group were treated with conventional therapy. Forty patients in treatment group were treated by Qishen Yiqi Dripping pills on the basis of control group. Treatment lasted 8 weeks. Level of cardiac function, 6 min walking distance,echocardiography index, plasma NT-proBNP level in two groups were observed before and after treatment. Result: After 8 weeks,level of cardiac function,6 min walk distance and left ventricular ejection fraction(LVEF) of patients in treatment group were significantly increased compared with control group(P<0.05),and level of plasma NT-proBNP was significantly decreased compared with control group(P<0.05). Conclusion: Qishen Yiqi Dripping pills can improve cardiac function, exercise tolerance, life quality and ventricular remodeling of patients with heart failure induced by schemic cardiomyopathy.