复方苦参注射液对小鼠的镇痛止血和抗应激作用

目的:观察复方苦参注射液对小鼠的镇痛、止血作用,和对荷瘤小鼠的抗应激作用.方法:苦参注射液剂量为含生药15.0,7.5,3.8 g·kg-1,ip.以热板法、扭体法(连续给药3d)、毛细管和断尾法(连续给药5d)分别观察复方苦参注射液对小鼠的镇痛和止血作用,并观察连续给药10 d对肝癌荷瘤小鼠耐缺氧和低温游泳时间的影响.结果:与对照组比较,复方苦参注射液高、中剂量可明显提高小鼠的热痛阈,显著延长小鼠扭体的潜伏期,显著减少扭体次数,明显缩短小鼠的凝血和出血时间,并可明显延长肝癌荷瘤小鼠的耐缺氧时间和低温游泳时间.结论:复方苦参注射液具有明显的镇痛和止血作用,并能增强荷瘤小鼠的抗应激能力.

Effects of Compound Kushen Injection on Analgesia, Hemostasis and Anti-stress in Mice

Objective: To observe the effects of Compound Kushen Injection on analgesia, hemostasis in mouse, and to observe to the anti-stress (induced by hypoxia and low temperature swimming) effect of the injection in tumor-bearing mice. Method: The hot plate method, the body-twisting method, capillary and broken tail method were used for evaluating the effects on analgesia and hemostasis accordingly, anti-stress effect of the injection was observed in the hepato-tumor-bearing mice. Result: Compared with controls, compound Kushen injection of 4, 2, 1 g·kg^-1 could obviously increase the pain threshold for heat in mice, significantly extend the body-twisting incubation period and reduce the counting, obviously reduce the blood coagulation and bleeding time, and significantly prolong the hypoxia tolerance duration and low temperature swimming time in the tumor-bearing mice. Conclusion: Compound Kushen Injection has obvious analgesia and hemostatic effect, and can enhance the anti-stress ability in tumor-bearing mice.