玉屏风散联合督脉铺灸对变应性鼻炎患者血清IL-6,cAMP,cGMP的影响

目的:探讨玉屏风散联合督脉铺灸对变应性鼻炎(AR)患者血清白细胞介素-6(IL-6),环磷酸腺苷(c AMP),环磷酸鸟苷(c GMP)的影响。方法:选取2013年6月至2016年6月河南省中医院收治的AR患者100例,依据治疗方法分为铺灸组和玉屏风组,每组50例,铺灸组患者给予西替利嗪+督脉铺灸治疗,玉屏风组患者在此基础上给予玉屏风颗粒治疗,采用酶联免疫吸附法检测血清IL-6,c GMP,c AMP水平,分析所有患者治疗前后血清IL-6,c GMP,c AMP水平和喷嚏、流涕、鼻塞、鼻痒消失时间及治疗疗效、不良反应、复发等情况。结果:铺灸组和玉屏风组治疗后血清IL-6,c GMP,c AMP水平明显低于本组治疗前,玉屏风组治疗后血清IL-6,c GMP水平明显低于铺灸组,玉屏风组治疗后血清c AMP水平明显高于铺灸组(P0.05);玉屏风组喷嚏、流涕、鼻塞、鼻痒消失时间明显低于铺灸组,玉屏风组治疗有效率明显高于铺灸组(P0.05),两组均无严重不良反应发生;随访1年期间,玉屏风组复发率明显低于铺灸组(P0.05)。结论:玉屏风颗粒联合督脉铺灸治疗可有效提高AR患者的近远期疗效,可能与其更有效调节机体免疫功能平衡有关,且其具有良好的安全性,值得临床作进一步推广。

Effect of Yupingfeng San Combined with Governor Meridian Long-snake Moxibustion on Serum IL-6, cAMP, cGMP in Patients with Allergic Rhinitis

Objective: To discuss the effect of Yupingfeng San combined with governor meridian long-snake moxibustion on serum interleukin-6 (IL-6), cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP) in patients with allergic rhinitis (AR). Method: A total of 100 patients with AR treated from June 2013 to June 2016 in Henan Province Hospital of Traditional Chinese Medicine were selected. According to the treatment method, all of the patients were divided into long-snake moxibustion group and Yupingfeng group, with 50 cases in each group.Long-snake moxibustion group was given cetirizine + governor vessel long-snake moxibustion treatment,Yupingfeng group on the basis was given Yupingfeng granules treatment, Serum IL-6, cGMP, cAMP levels were detected by enzyme-linked immunosorbent method. Before and after treatment, serum IL-6, cGMP, cAMP levels, sneezing, runny nose, stuffy nose, nasal itching disappearance time, efficacy, adverse reaction, recurrence of all of the patients were analyzed. Result: After treatment, serum IL-6, cGMP levels of Yupingfeng San group and long-snake moxibustion group were significantly lower than those before treatment; after treatment, serum IL-6, cGMP levels of Yupingfeng group were significantly lower than those of long-snake moxibustion group; after treatment, serum cAMP level of Yupingfeng group was significantly higher than that of long-snake moxibustion group, with statistically significant differences (P<0.05). Sneezing, runny nose, stuffy nose, nasal itching disappearance time of Yupingfeng group were significantly lower than those of long-snake moxibustion group; therapeutic response rate of Yupingfeng group was significantly higher than that of long-snake moxibustion group, with statistically significant differences (P<0.05) but no serious adverse reaction in the two groups. The recurrence rate of Yupingfeng San group was significantly lower than that of long-snake moxibustion group, with statistically significant differences (P<0.05). Conclusion: Yupingfeng San combined with governor meridian long-snake moxibustion can effectively improve the short-term and long-term efficacy of patients with AR, which may be related to more effective regulation of body immune function. It has a good safety, and is worth further clinical promotion.