中医辨证维持治疗对晚期非小细胞肺癌化疗后的生存质量及无进展生存期的影响

目的:探讨中医辨证维持治疗对晚期非小细胞肺癌(NSCLC)化疗后生存质量及无进展生存期的影响.方法:76例晚期NSCLC患者随机分成观察组39例和对照组37例.两组均采用一线化疗方案4～6周.对照组定期随访.观察组采用中医辨证治疗.随访统计无疾病进展生存期(PFS),于治疗前及治疗后12周评价患者生活质量及临床症状.结果:治疗后观察组躯体功能、角色功能情绪功能和整体生活质量评分均高于对照组(P＜0.05)；治疗后观察组疲乏、呼吸困难、失眠、食欲丧失积分低于对照组(P＜0.05)；观察组PFS(7.2±1.32)个月,优于对照组的(4.4±0.57)个月(P＜0.01)；治疗后观察组咳嗽、咯痰、痰中带血、气短、胸痛、口干咽燥、神疲乏力、食欲不振、失眠等评分均明显低于对照组(P＜0.01).结论:中医辨证维持治疗化疗后晚期NSCLC,能改善患者生存质量,改善临床症状,并能延长患者的PFS期.

Effect of Maintenance Treatment by Traditional Chinese Medicine Syndrome Differentiation on Life Quality and Progress-free Survival of Patients with Advanced Non-small Cell Lung Cancer after Chemotherapy

Objective:To investigate the effect of maintenance treatment by traditional Chinese medicine (TCM) syndrome differentiation on life quality and progress-free survival (PFS) of patients with advanced non-small cell lung cancer (NSCLC) treated with chemotherapy. Method: Seventy-six patients with NSCLC were randomly divided into observation group and control group (n=39 each). The two groups were treated with first-line chemotherapy for 4 to 6 weeks. The control group was regularly followed-up. The observation group was received TCM syndrome differentiation treatment. Follow-up data about PFS was analyzed, besides, life quality and clinic symptom of patients before and 12 weeks after treatment were evaluated. Result: After treatment, physical function, role function, emotional function and total life quality in observation group were higher than those in control group (P<0.05). Fatigue, dyspnoea, insomnia and appetite loss scores in observation group were lower than those in control group (P<0.05). PFS of observation group was (7.2±1.32) months, which was longer than (4.4±0.57) months of control group (P<0.01). Scores of cough, phlegm, blood in phlegm, shortness of breath, chest pain, lassitude, anorexia, insomnia and others in observation group were lower than those in control group (P<0.01). Conclusion: Maintenance treatment by TCM syndrome differentiation on patients with advanced NSCLC can improve life quality and clinic symptom, and prolong PFS of patients.