| 栀子降尿酸有效部位研究 |
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| 引用本文： | 朱继孝,曾金祥,罗光明,朱玉野,王晓云,吴波,师晶晶,徐赟峰.栀子降尿酸有效部位研究[J].中国实验方剂学杂志,2012,18(14):159-161. |
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| 作者姓名： | 朱继孝 曾金祥 罗光明 朱玉野 王晓云 吴波 师晶晶 徐赟峰 |
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| 作者单位： | 江西中医学院江西省中药种质资源工程技术研究中心,南昌,330004 |
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| 基金项目： | 国家"十二五"科技支撑计划项目(2011BAI04B01) |
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| 摘 要： | 目的:确定栀子降尿酸作用有效部位.方法:用系统溶剂法提取分离得到4个部位,分别为石油醚部位、乙酸乙酯部位、正丁醇部位和水液部位,采用氧嗪酸钾盐诱导的小鼠急性高尿酸血症模型,研究栀子总提物和4个部位对高尿酸血症小鼠血清尿酸水平和肝脏黄嘌呤氧化酶的影响.结果:栀子总提物组、乙酸乙酯组和水组具有较好的降尿酸作用,栀子总提物组、石油醚组和水组能够较好的抑制黄嘌呤氧化酶的活性.栀子总提取物和各部位提取物对正常小鼠血清尿酸水平没有显著影响.结论:栀子乙酸乙酯提取部位和水液部位为降尿酸活性部位,其降尿酸作用部分机制是通过抑制黄嘌呤氧化酶的活性.
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| 关 键 词： | 栀子 降尿酸 有效部位 黄嘌呤氧化酶 |
| 收稿时间： | 2011/11/22 0:00:00 |
Study on Effective Part of Anti-hyperuricemia in Gardeniae Fructus |
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| ZHU Ji-xiao,ZENG Jin-xiang,LUO Guang-ming,ZHU Yu-ye,WANG Xiao-yun,WU Bo,SHI Jing-jing and XU Yun-feng.Study on Effective Part of Anti-hyperuricemia in Gardeniae Fructus[J].China Journal of Experimental Traditional Medical Formulae,2012,18(14):159-161. |
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| Authors: | ZHU Ji-xiao ZENG Jin-xiang LUO Guang-ming ZHU Yu-ye WANG Xiao-yun WU Bo SHI Jing-jing and XU Yun-feng |
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| Institution: | The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China |
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| Abstract: | Objective: To determine the effective part of anti-hyperuricemia in Gardeniae Fructus. Method: Four fractions were obtained by systematic solvent extraction, petrol ether extract, ethyl acetate extract, butanol extract and water-soluble part.Total extract of Gardenia Fructus (TEG) and its different extracts were administrated to hyperuricemia mice induced by potassium oxonate, then the level of uric acid and xanthine oxidase in hyperuricemia mice were observed. Result: TEG, ethyl acetate extract and water-soluble part could obviously reduce the level of serum uric acid in hyperuricemia mice, TEG, petrol ether extract and water-soluble part could obviously inhibit the activity of and xanthine oxidase in the liver. TEG and its different extracts had no effect on the level of serum uric acid in normal mice. Conclusion: Ethyl acetate extract and water-soluble part from Gardeniae Fructus are the active fraction for anti-hyperuricemia, and the effect is related to its inhibition of xanthine oxidase. |
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| Keywords: | Gardeniae Fructus anti-hyperuricemia effective part xanthine oxidase |
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