丹参注射液联合厄贝沙坦氢氯噻嗪对难治性高血压的降压及保肾作用

目的:观察丹参注射液联合厄贝沙坦氢氯噻嗪治疗难治性高血压的临床疗效.方法:将符合病例入选标准的120例难治性高血压患者随机分为观察组、对照组,每组60例.两组患者均嘱合理饮食,对照组治以厄贝沙坦氢氯噻嗪片,1次/d,1片/次.观察组在服用厄贝沙坦氢氯噻嗪片的基础上以丹参注射液20 mL+200 mL生理盐水静脉滴注,1次/d.2组均以治疗2周为1个疗程,治疗2个疗程后评价疗效.结果:显效率观察组76.67％,对照组53.33％,两组差异显著(P＜0.05).总有效率观察组93.33％,对照组73.33％,两组差异显著(P＜0.05).两组收缩压(SBP),舒张压(DBP)治疗后均明显下降(P＜0.05),观察组改善优于对照组(P＜0.05).两组治疗后血清胱抑素( Cys C)、尿mALB,血肌酐(SCr),尿素氮(BUN)明显改善(P＜0.05),观察组改善优于对照组(P＜0.05).两组不良反应发生率无统计学差异.结论:观察丹参注射液联合厄贝沙坦氢氯噻嗪治疗难治性高血压临床疗效显著,降压作用好,且可改善血清Cys C,尿mALB,SCr,BUN.

Salvia Miltiorrhiza Injection Combined with Irbesartan Hydrochlorothiazide in Treatment of Refractory Hypertension Example Curative Effect Observation

Objective: Observation of Danshen injection combined with irbesartan hydrochlorothiazide in the treatment of refractory hypertension patients. Method: With a case in sixty patients with refractory hypertension were randomly divided into the observation group and the control group,30 cases in each group. Two groups of patients were prescribed diet, the control group treated with irbesartan and hydrochlorothiazide tablets,1 time/d,1 pill/time. In the observation group with irbesartan and hydrochlorothiazide tablets on the basis of Salvia miltiorrhiza injection 20 mL+200 mL intravenous saline infusion,1 times/d. The 2 groups were treated for 2 weeks with 1 courses of treatment, after 2 courses of treatment efficacy. Result: Significant efficiency was observed in group 76.67%, control group 53.33%, two groups had significant difference (P<0.05). The total efficiency of the observation group 93.33%, control group 73.33%, two groups had significant difference (P<0.05). Two groups of systolic blood pressure(SBP), diastolic blood pressure(DBP) after treatment were significantly decreased (P<0.05), the observation group is better than control group (P<0.05). The two groups after treatment, serum cystation C(Cys C), serum creatinine(SCr), urea nitrogen(BUN) and urinary mALB were significantly improved (P<0.05), the observation group is better than control group (P<0.05). The two group is China should occur rate showed no significant difference. Conclusion: The effect of Danshen injection combined with irbesartan hydrochlorothiazide in the treatment of refractory hypertension clinical curative effect is remarkable, the antihypertensive effect of good, and can have good serum Cys C, mALB, SCr, BUN in urine.