胆木叶片抗大鼠急性咽炎作用研究

目的:探讨胆木叶片对大鼠急性咽炎的治疗作用。方法:取大鼠随机分为空白组、模型组、阿司匹林组(0.20g·kg~(-1))、胆木叶片组(按生药量计,25.8,12.9,6.5 g·kg~(-1)),每天2次,连续ig给药3 d。采用氨水喷雾刺激,观察大鼠一般状态,病理改变情况,测定咽部组织一氧化氮(NO),髓过氧化物酶(MPO)等指标;采用局部注射金黄色葡萄球菌2次后,观察大鼠一般状态、测量体温,观察细菌菌落数,测定NO,MPO等指标。结果:氨水喷雾刺激后,与正常组比较,模型组咽部组织NO,MPO含量较空白组明显升高(P0.01);与模型组比较,胆木叶片高、中、低剂量组及阿司匹林组咽部组织NO,MPO含量明显降低,有显著统计学意义(P0.01,P0.05)。局部注射金黄色葡萄球菌后,与正常组比较,模型组血清NO,MPO含量明显升高,菌落数增多,体温升高(P0.01);与模型组比较胆木叶片高、中剂量组及阿司匹林组血清NO,MPO含量明显降低,菌落数明显减少,体温降低(P0.01,P0.05)。结论:胆木叶片对急性咽炎有较好的治疗作用。

Effect of Leaves of Nauclea officinalis Tablet on Actue Pharyngitis of Rats

Objective: To explore the effects of the leaves of Nauclea officinalis tableton on acute pharyngitis of rat models. Method: Rats were randomly divided into 6 groups,normal group,model group,aspirin group(0.20 g·kg^-1),the leaves of N. officinalis tablets groups(25.8,12.9,6.5 g·kg^-1).Each drug was administrated to mice orally twice a day for 3 days.Their commonly living conditions and bacterial colony were observed, the pharyngeal tissues were pathologically examined,the nitric oxide(NO) and myeloperoxidase(MPO)of the pharyngeal tissues and serum were determined,and the temperature were tested by directly spraying ammonia water and applying Staphylococcus aureus into pharyngeal mucosa. Result: The leaves of N. officinalis tablet could be decrease the content of NO and MPO in the pharyngeal tissues and serum,and also decrease the temperature;pathologic changes of rats with actue pharyngitis were improved in different degree;the leaves of N. officinalis tablets restrain the growth of the bacteria. Conclusion: The leaves of N. officinalis tablet has a good curative effect on acute pharyngitis.